The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review

Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier...

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Detalles Bibliográficos
Autores principales: de Morais, Rafael Martins, Sobrinho, Alaor Barra, de Souza Silva, Calliandra Maria, de Oliveira, Jamila Reis, da Silva, Izabel Cristina Rodrigues, de Toledo Nóbrega, Otávio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282135/
https://www.ncbi.nlm.nih.gov/pubmed/30595693
http://dx.doi.org/10.1155/2018/9128754
Descripción
Sumario:Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper's objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.

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