The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review

Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier...

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Autores principales: de Morais, Rafael Martins, Sobrinho, Alaor Barra, de Souza Silva, Calliandra Maria, de Oliveira, Jamila Reis, da Silva, Izabel Cristina Rodrigues, de Toledo Nóbrega, Otávio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282135/
https://www.ncbi.nlm.nih.gov/pubmed/30595693
http://dx.doi.org/10.1155/2018/9128754
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author de Morais, Rafael Martins
Sobrinho, Alaor Barra
de Souza Silva, Calliandra Maria
de Oliveira, Jamila Reis
da Silva, Izabel Cristina Rodrigues
de Toledo Nóbrega, Otávio
author_facet de Morais, Rafael Martins
Sobrinho, Alaor Barra
de Souza Silva, Calliandra Maria
de Oliveira, Jamila Reis
da Silva, Izabel Cristina Rodrigues
de Toledo Nóbrega, Otávio
author_sort de Morais, Rafael Martins
collection PubMed
description Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper's objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.
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spelling pubmed-62821352018-12-30 The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review de Morais, Rafael Martins Sobrinho, Alaor Barra de Souza Silva, Calliandra Maria de Oliveira, Jamila Reis da Silva, Izabel Cristina Rodrigues de Toledo Nóbrega, Otávio Int J Endocrinol Review Article Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper's objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer. Hindawi 2018-11-14 /pmc/articles/PMC6282135/ /pubmed/30595693 http://dx.doi.org/10.1155/2018/9128754 Text en Copyright © 2018 Rafael Martins de Morais et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de Morais, Rafael Martins
Sobrinho, Alaor Barra
de Souza Silva, Calliandra Maria
de Oliveira, Jamila Reis
da Silva, Izabel Cristina Rodrigues
de Toledo Nóbrega, Otávio
The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
title The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
title_full The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
title_fullStr The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
title_full_unstemmed The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
title_short The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
title_sort role of the nis (slc5a5) gene in papillary thyroid cancer: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282135/
https://www.ncbi.nlm.nih.gov/pubmed/30595693
http://dx.doi.org/10.1155/2018/9128754
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