Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previously we discovered bacteriophage-encoded Cas9-specific ant...

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Detalles Bibliográficos
Autores principales: Lee, Jooyoung, Mir, Aamir, Edraki, Alireza, Garcia, Bianca, Amrani, Nadia, Lou, Hannah E., Gainetdinov, Ildar, Pawluk, April, Ibraheim, Raed, Gao, Xin D., Liu, Pengpeng, Davidson, Alan R., Maxwell, Karen L., Sontheimer, Erik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282205/
https://www.ncbi.nlm.nih.gov/pubmed/30514786
http://dx.doi.org/10.1128/mBio.02321-18

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