Avoidance of Trinucleotide Corresponding to Consensus Protospacer Adjacent Motif Controls the Efficiency of Prespacer Selection during Primed Adaptation

CRISPR DNA arrays of unique spacers separated by identical repeats ensure prokaryotic immunity through specific targeting of foreign nucleic acids complementary to spacers. New spacers are acquired into a CRISPR array in a process of CRISPR adaptation. Selection of foreign DNA fragments to be integr...

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Detalles Bibliográficos
Autores principales: Musharova, Olga, Vyhovskyi, Danylo, Medvedeva, Sofia, Guzina, Jelena, Zhitnyuk, Yulia, Djordjevic, Marko, Severinov, Konstantin, Savitskaya, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282206/
https://www.ncbi.nlm.nih.gov/pubmed/30514784
http://dx.doi.org/10.1128/mBio.02169-18

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