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Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study

BACKGROUND: Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal...

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Autores principales: Tang, Yongquan, Liu, Zhihong, Liang, Jiayu, Zhang, Ruochen, Wu, Kan, Zou, Zijun, Zhou, Chuan, Zhang, Fuxun, Lu, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282248/
https://www.ncbi.nlm.nih.gov/pubmed/30522461
http://dx.doi.org/10.1186/s12894-018-0427-3
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author Tang, Yongquan
Liu, Zhihong
Liang, Jiayu
Zhang, Ruochen
Wu, Kan
Zou, Zijun
Zhou, Chuan
Zhang, Fuxun
Lu, Yiping
author_facet Tang, Yongquan
Liu, Zhihong
Liang, Jiayu
Zhang, Ruochen
Wu, Kan
Zou, Zijun
Zhou, Chuan
Zhang, Fuxun
Lu, Yiping
author_sort Tang, Yongquan
collection PubMed
description BACKGROUND: Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal cell cancer. METHODS: We retrospectively included patients hospitalized for kidney cancer from January 2009 to May 2014. First, the receiver operating characteristic analysis was used to define the best cut-off of an early post-operative serum albumin level in determining the prognosis, from which survival analysis was performed. RESULTS: A total of 329 patients were included. The median duration of follow-up was 54.8 months. Patients with an early post-operative serum albumin level < 32 g/L had a significantly shorter median recurrence-free survival (RFS; 49.1 versus 56.5 months, P = 0.001) and median overall survival (OS; 52.2 versus 57.0 months, P = 0.049) than patients with an early post-operative serum albumin level ≥ 32 g/L. After adjusting for age, BMI, tumor stage, post-operative hemoglobin concentration, and pre-operative albumin, globulin, and hemoglobin levels, multivariate Cox regression showed that an early post-operative serum albumin level < 32 g/L was an independent prognostic factor associated with a decreased RFS (HR = 3.60; 95% CI,1.05–12.42 [months], P = 0.042) and decreased OS (HR = 9.95; 95% CI, 1.81–54.80 [months], P = 0.008). CONCLUSION: An early post-operative serum albumin level < 32 g/L is an independent prognostic factor leading to an unfavorable RFS and OS. Prospective trials and further studies involving additional patients are warranted.
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spelling pubmed-62822482018-12-10 Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study Tang, Yongquan Liu, Zhihong Liang, Jiayu Zhang, Ruochen Wu, Kan Zou, Zijun Zhou, Chuan Zhang, Fuxun Lu, Yiping BMC Urol Research Article BACKGROUND: Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal cell cancer. METHODS: We retrospectively included patients hospitalized for kidney cancer from January 2009 to May 2014. First, the receiver operating characteristic analysis was used to define the best cut-off of an early post-operative serum albumin level in determining the prognosis, from which survival analysis was performed. RESULTS: A total of 329 patients were included. The median duration of follow-up was 54.8 months. Patients with an early post-operative serum albumin level < 32 g/L had a significantly shorter median recurrence-free survival (RFS; 49.1 versus 56.5 months, P = 0.001) and median overall survival (OS; 52.2 versus 57.0 months, P = 0.049) than patients with an early post-operative serum albumin level ≥ 32 g/L. After adjusting for age, BMI, tumor stage, post-operative hemoglobin concentration, and pre-operative albumin, globulin, and hemoglobin levels, multivariate Cox regression showed that an early post-operative serum albumin level < 32 g/L was an independent prognostic factor associated with a decreased RFS (HR = 3.60; 95% CI,1.05–12.42 [months], P = 0.042) and decreased OS (HR = 9.95; 95% CI, 1.81–54.80 [months], P = 0.008). CONCLUSION: An early post-operative serum albumin level < 32 g/L is an independent prognostic factor leading to an unfavorable RFS and OS. Prospective trials and further studies involving additional patients are warranted. BioMed Central 2018-12-06 /pmc/articles/PMC6282248/ /pubmed/30522461 http://dx.doi.org/10.1186/s12894-018-0427-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tang, Yongquan
Liu, Zhihong
Liang, Jiayu
Zhang, Ruochen
Wu, Kan
Zou, Zijun
Zhou, Chuan
Zhang, Fuxun
Lu, Yiping
Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
title Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
title_full Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
title_fullStr Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
title_full_unstemmed Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
title_short Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
title_sort early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282248/
https://www.ncbi.nlm.nih.gov/pubmed/30522461
http://dx.doi.org/10.1186/s12894-018-0427-3
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