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Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study
BACKGROUND: Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282248/ https://www.ncbi.nlm.nih.gov/pubmed/30522461 http://dx.doi.org/10.1186/s12894-018-0427-3 |
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author | Tang, Yongquan Liu, Zhihong Liang, Jiayu Zhang, Ruochen Wu, Kan Zou, Zijun Zhou, Chuan Zhang, Fuxun Lu, Yiping |
author_facet | Tang, Yongquan Liu, Zhihong Liang, Jiayu Zhang, Ruochen Wu, Kan Zou, Zijun Zhou, Chuan Zhang, Fuxun Lu, Yiping |
author_sort | Tang, Yongquan |
collection | PubMed |
description | BACKGROUND: Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal cell cancer. METHODS: We retrospectively included patients hospitalized for kidney cancer from January 2009 to May 2014. First, the receiver operating characteristic analysis was used to define the best cut-off of an early post-operative serum albumin level in determining the prognosis, from which survival analysis was performed. RESULTS: A total of 329 patients were included. The median duration of follow-up was 54.8 months. Patients with an early post-operative serum albumin level < 32 g/L had a significantly shorter median recurrence-free survival (RFS; 49.1 versus 56.5 months, P = 0.001) and median overall survival (OS; 52.2 versus 57.0 months, P = 0.049) than patients with an early post-operative serum albumin level ≥ 32 g/L. After adjusting for age, BMI, tumor stage, post-operative hemoglobin concentration, and pre-operative albumin, globulin, and hemoglobin levels, multivariate Cox regression showed that an early post-operative serum albumin level < 32 g/L was an independent prognostic factor associated with a decreased RFS (HR = 3.60; 95% CI,1.05–12.42 [months], P = 0.042) and decreased OS (HR = 9.95; 95% CI, 1.81–54.80 [months], P = 0.008). CONCLUSION: An early post-operative serum albumin level < 32 g/L is an independent prognostic factor leading to an unfavorable RFS and OS. Prospective trials and further studies involving additional patients are warranted. |
format | Online Article Text |
id | pubmed-6282248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62822482018-12-10 Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study Tang, Yongquan Liu, Zhihong Liang, Jiayu Zhang, Ruochen Wu, Kan Zou, Zijun Zhou, Chuan Zhang, Fuxun Lu, Yiping BMC Urol Research Article BACKGROUND: Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal cell cancer. METHODS: We retrospectively included patients hospitalized for kidney cancer from January 2009 to May 2014. First, the receiver operating characteristic analysis was used to define the best cut-off of an early post-operative serum albumin level in determining the prognosis, from which survival analysis was performed. RESULTS: A total of 329 patients were included. The median duration of follow-up was 54.8 months. Patients with an early post-operative serum albumin level < 32 g/L had a significantly shorter median recurrence-free survival (RFS; 49.1 versus 56.5 months, P = 0.001) and median overall survival (OS; 52.2 versus 57.0 months, P = 0.049) than patients with an early post-operative serum albumin level ≥ 32 g/L. After adjusting for age, BMI, tumor stage, post-operative hemoglobin concentration, and pre-operative albumin, globulin, and hemoglobin levels, multivariate Cox regression showed that an early post-operative serum albumin level < 32 g/L was an independent prognostic factor associated with a decreased RFS (HR = 3.60; 95% CI,1.05–12.42 [months], P = 0.042) and decreased OS (HR = 9.95; 95% CI, 1.81–54.80 [months], P = 0.008). CONCLUSION: An early post-operative serum albumin level < 32 g/L is an independent prognostic factor leading to an unfavorable RFS and OS. Prospective trials and further studies involving additional patients are warranted. BioMed Central 2018-12-06 /pmc/articles/PMC6282248/ /pubmed/30522461 http://dx.doi.org/10.1186/s12894-018-0427-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Tang, Yongquan Liu, Zhihong Liang, Jiayu Zhang, Ruochen Wu, Kan Zou, Zijun Zhou, Chuan Zhang, Fuxun Lu, Yiping Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
title | Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
title_full | Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
title_fullStr | Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
title_full_unstemmed | Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
title_short | Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
title_sort | early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282248/ https://www.ncbi.nlm.nih.gov/pubmed/30522461 http://dx.doi.org/10.1186/s12894-018-0427-3 |
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