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EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation

BACKGROUND: Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resulting in differential gene regulation. However, it remains unknown how PRC2 specifi...

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Detalles Bibliográficos
Autores principales:	Mu, Weipeng, Starmer, Joshua, Yee, Della, Magnuson, Terry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282306/ https://www.ncbi.nlm.nih.gov/pubmed/30522506 http://dx.doi.org/10.1186/s13072-018-0242-9

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