Cargando…

Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application

BACKGROUND: Carbonate apatite (CO(3)Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO(3)Ap induce apatite crystal formation with good adaptation prov...

Descripción completa

Detalles Bibliográficos
Autores principales: Zakaria, Myrna Nurlatifah, Cahyanto, Arief, El-Ghannam, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282351/
https://www.ncbi.nlm.nih.gov/pubmed/30546914
http://dx.doi.org/10.1186/s40824-018-0146-6
_version_ 1783378974586437632
author Zakaria, Myrna Nurlatifah
Cahyanto, Arief
El-Ghannam, Ahmed
author_facet Zakaria, Myrna Nurlatifah
Cahyanto, Arief
El-Ghannam, Ahmed
author_sort Zakaria, Myrna Nurlatifah
collection PubMed
description BACKGROUND: Carbonate apatite (CO(3)Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO(3)Ap induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. The aim of this study is to investigate modification of CO(3)Ap cement combined with SCPC, later term as CO(3)Ap-SCPC cement (CAS) in means of its chemical (Calcium release) and physical properties (setting time, DTS and pH value). METHODS: The study consist of three groups; group 1 (100% calcium hydroxide, group 2 CO(3)Ap (60% DCPA: 40% vaterite, and group 3 CAS (60% DCPA: 20% vaterite: 20% SCPC. Distilled water was employed as a solution for group 1, and 0.2 mol/L Na(3)PO(4) used for group 2 and group 3. Samples were evaluated with respect to important properties for pulp capping application such as pH, setting time, mechanical strength and calcium release evaluation. RESULTS: The fastest setting time was in CO(3)Ap cement group without SCPC, while the addition of 20% SCPC slightly increase the pH value but did not improved the cement mechanical strength, however, the mechanical strength of both CO(3)Ap groups were significantly higher than calcium hydroxide. All three groups released calcium ions and had alkaline pH. Highest pH level, as well as calcium released level, was in the control group. CONCLUSION: The CAS cement had good mechanical and acceptable chemical properties for pulp capping application compared to calcium hydroxide as a gold standard. However, improvements and in vivo studies are to be carried out with the further development of this material.
format Online
Article
Text
id pubmed-6282351
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-62823512018-12-13 Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application Zakaria, Myrna Nurlatifah Cahyanto, Arief El-Ghannam, Ahmed Biomater Res Research Article BACKGROUND: Carbonate apatite (CO(3)Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO(3)Ap induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. The aim of this study is to investigate modification of CO(3)Ap cement combined with SCPC, later term as CO(3)Ap-SCPC cement (CAS) in means of its chemical (Calcium release) and physical properties (setting time, DTS and pH value). METHODS: The study consist of three groups; group 1 (100% calcium hydroxide, group 2 CO(3)Ap (60% DCPA: 40% vaterite, and group 3 CAS (60% DCPA: 20% vaterite: 20% SCPC. Distilled water was employed as a solution for group 1, and 0.2 mol/L Na(3)PO(4) used for group 2 and group 3. Samples were evaluated with respect to important properties for pulp capping application such as pH, setting time, mechanical strength and calcium release evaluation. RESULTS: The fastest setting time was in CO(3)Ap cement group without SCPC, while the addition of 20% SCPC slightly increase the pH value but did not improved the cement mechanical strength, however, the mechanical strength of both CO(3)Ap groups were significantly higher than calcium hydroxide. All three groups released calcium ions and had alkaline pH. Highest pH level, as well as calcium released level, was in the control group. CONCLUSION: The CAS cement had good mechanical and acceptable chemical properties for pulp capping application compared to calcium hydroxide as a gold standard. However, improvements and in vivo studies are to be carried out with the further development of this material. BioMed Central 2018-12-06 /pmc/articles/PMC6282351/ /pubmed/30546914 http://dx.doi.org/10.1186/s40824-018-0146-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zakaria, Myrna Nurlatifah
Cahyanto, Arief
El-Ghannam, Ahmed
Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
title Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
title_full Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
title_fullStr Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
title_full_unstemmed Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
title_short Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
title_sort calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282351/
https://www.ncbi.nlm.nih.gov/pubmed/30546914
http://dx.doi.org/10.1186/s40824-018-0146-6
work_keys_str_mv AT zakariamyrnanurlatifah calciumreleaseandphysicalpropertiesofmodifiedcarbonateapatitecementaspulpcappingagentindentalapplication
AT cahyantoarief calciumreleaseandphysicalpropertiesofmodifiedcarbonateapatitecementaspulpcappingagentindentalapplication
AT elghannamahmed calciumreleaseandphysicalpropertiesofmodifiedcarbonateapatitecementaspulpcappingagentindentalapplication