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Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application
BACKGROUND: Carbonate apatite (CO(3)Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO(3)Ap induce apatite crystal formation with good adaptation prov...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282351/ https://www.ncbi.nlm.nih.gov/pubmed/30546914 http://dx.doi.org/10.1186/s40824-018-0146-6 |
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author | Zakaria, Myrna Nurlatifah Cahyanto, Arief El-Ghannam, Ahmed |
author_facet | Zakaria, Myrna Nurlatifah Cahyanto, Arief El-Ghannam, Ahmed |
author_sort | Zakaria, Myrna Nurlatifah |
collection | PubMed |
description | BACKGROUND: Carbonate apatite (CO(3)Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO(3)Ap induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. The aim of this study is to investigate modification of CO(3)Ap cement combined with SCPC, later term as CO(3)Ap-SCPC cement (CAS) in means of its chemical (Calcium release) and physical properties (setting time, DTS and pH value). METHODS: The study consist of three groups; group 1 (100% calcium hydroxide, group 2 CO(3)Ap (60% DCPA: 40% vaterite, and group 3 CAS (60% DCPA: 20% vaterite: 20% SCPC. Distilled water was employed as a solution for group 1, and 0.2 mol/L Na(3)PO(4) used for group 2 and group 3. Samples were evaluated with respect to important properties for pulp capping application such as pH, setting time, mechanical strength and calcium release evaluation. RESULTS: The fastest setting time was in CO(3)Ap cement group without SCPC, while the addition of 20% SCPC slightly increase the pH value but did not improved the cement mechanical strength, however, the mechanical strength of both CO(3)Ap groups were significantly higher than calcium hydroxide. All three groups released calcium ions and had alkaline pH. Highest pH level, as well as calcium released level, was in the control group. CONCLUSION: The CAS cement had good mechanical and acceptable chemical properties for pulp capping application compared to calcium hydroxide as a gold standard. However, improvements and in vivo studies are to be carried out with the further development of this material. |
format | Online Article Text |
id | pubmed-6282351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62823512018-12-13 Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application Zakaria, Myrna Nurlatifah Cahyanto, Arief El-Ghannam, Ahmed Biomater Res Research Article BACKGROUND: Carbonate apatite (CO(3)Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO(3)Ap induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. The aim of this study is to investigate modification of CO(3)Ap cement combined with SCPC, later term as CO(3)Ap-SCPC cement (CAS) in means of its chemical (Calcium release) and physical properties (setting time, DTS and pH value). METHODS: The study consist of three groups; group 1 (100% calcium hydroxide, group 2 CO(3)Ap (60% DCPA: 40% vaterite, and group 3 CAS (60% DCPA: 20% vaterite: 20% SCPC. Distilled water was employed as a solution for group 1, and 0.2 mol/L Na(3)PO(4) used for group 2 and group 3. Samples were evaluated with respect to important properties for pulp capping application such as pH, setting time, mechanical strength and calcium release evaluation. RESULTS: The fastest setting time was in CO(3)Ap cement group without SCPC, while the addition of 20% SCPC slightly increase the pH value but did not improved the cement mechanical strength, however, the mechanical strength of both CO(3)Ap groups were significantly higher than calcium hydroxide. All three groups released calcium ions and had alkaline pH. Highest pH level, as well as calcium released level, was in the control group. CONCLUSION: The CAS cement had good mechanical and acceptable chemical properties for pulp capping application compared to calcium hydroxide as a gold standard. However, improvements and in vivo studies are to be carried out with the further development of this material. BioMed Central 2018-12-06 /pmc/articles/PMC6282351/ /pubmed/30546914 http://dx.doi.org/10.1186/s40824-018-0146-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zakaria, Myrna Nurlatifah Cahyanto, Arief El-Ghannam, Ahmed Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
title | Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
title_full | Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
title_fullStr | Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
title_full_unstemmed | Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
title_short | Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
title_sort | calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282351/ https://www.ncbi.nlm.nih.gov/pubmed/30546914 http://dx.doi.org/10.1186/s40824-018-0146-6 |
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