NmeCas9 is an intrinsically high-fidelity genome-editing platform

BACKGROUND: The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can induce significant levels of unintended mutations at near-c...

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Detalles Bibliográficos
Autores principales: Amrani, Nadia, Gao, Xin D., Liu, Pengpeng, Edraki, Alireza, Mir, Aamir, Ibraheim, Raed, Gupta, Ankit, Sasaki, Kanae E., Wu, Tong, Donohoue, Paul D., Settle, Alexander H., Lied, Alexandra M., McGovern, Kyle, Fuller, Chris K., Cameron, Peter, Fazzio, Thomas G., Zhu, Lihua Julie, Wolfe, Scot A., Sontheimer, Erik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282386/
https://www.ncbi.nlm.nih.gov/pubmed/30518407
http://dx.doi.org/10.1186/s13059-018-1591-1

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