Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

Neutrophil serine proteases (NSPs), such as neutrophil elastase (NE), are activated by dipeptidyl peptidase 1 (DPP1) during neutrophil maturation. High NSP levels can be detrimental, particularly in lung tissue, and inhibition of NSPs is therefore an interesting therapeutic opportunity in multiple l...

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Detalles Bibliográficos
Autores principales: Palmér, Robert, Mäenpää, Jukka, Jauhiainen, Alexandra, Larsson, Bengt, Mo, John, Russell, Muir, Root, James, Prothon, Susanne, Chialda, Ligia, Forte, Pablo, Egelrud, Torbjörn, Stenvall, Kristina, Gardiner, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282495/
https://www.ncbi.nlm.nih.gov/pubmed/29484635
http://dx.doi.org/10.1002/cpt.1053

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