Cargando…

Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies

Progesterone plays an important role in the female reproductive system. However, there is also evidence that gynecologic disorders/diseases such as uterine fibroids and endometriosis are progesterone‐dependent. Steroidal and non‐steroidal selective progesterone receptor modulators (SPRMs) have shown...

Descripción completa

Detalles Bibliográficos
Autores principales:	Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282584/ https://www.ncbi.nlm.nih.gov/pubmed/30407750 http://dx.doi.org/10.1002/cmdc.201800487

Ejemplares similares

Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview
por: Schultze-Mosgau, Marcus-Hillert, et al.
Publicado: (2021)

Characterization of the Pharmacokinetics of Vilaprisan: Bioavailability, Excretion, Biotransformation, and Drug–Drug Interaction Potential
por: Schultze-Mosgau, Marcus-Hillert, et al.
Publicado: (2018)

Pharmacokinetics and Safety of the Novel Selective Progesterone Receptor Modulator Vilaprisan in Participants With Renal Impairment
por: Schultze‐Mosgau, Marcus‐Hillert, et al.
Publicado: (2020)

Effect of the Novel Selective Progesterone Receptor Modulator Vilaprisan on Ovarian Activity in Healthy Women
por: Schütt, Barbara, et al.
Publicado: (2017)

Effect of Food Intake on the Pharmacokinetics of the Selective Progesterone Receptor Modulator Vilaprisan: A Randomized Clinical Study in Healthy Postmenopausal Women
por: Schultze‐Mosgau, Marcus‐Hillert, et al.
Publicado: (2020)

Pharmacokinetics and Safety of the Selective Progesterone Receptor Modulator Vilaprisan in Chinese Healthy Postmenopausal Women
por: Liu, Hongzhong, et al.
Publicado: (2020)

Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation
por: Sutter, Gabriele, et al.
Publicado: (2021)

Effect of hepatic impairment on the pharmacokinetics of vilaprisan: An open‐label, single‐dose, parallel‐group study
por: Chattopadhyay, Niladri, et al.
Publicado: (2019)

The effects of vilaprisan on the pharmacodynamics and pharmacokinetics of a combined oral contraceptive—A randomized controlled trial
por: Schultze‐Mosgau, Marcus‐Hillert, et al.
Publicado: (2020)

Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies
por: Wagenfeld, Andrea, et al.
Publicado: (2016)

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876
por: Siebeneicher, Holger, et al.
Publicado: (2016)

Progesterone Actions and Resistance in Gynecological Disorders
por: MacLean, James A., et al.
Publicado: (2022)

BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients
por: Sugawara, Tatsuo, et al.
Publicado: (2016)

No impact of time to treatment initiation for head and neck cancer in a tertiary university center in 2003, 2008 and 2013
por: Kouka, Mussab, et al.
Publicado: (2022)

Management of dental extraction in patients with Haemophilia A and B: A report of 58 extractions
por: Peisker, Andre, et al.
Publicado: (2014)

Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist
por: Mesch, Stefanie, et al.
Publicado: (2023)

Bayes or not Bayes, is this the question?
por: K. Hackenberger, Branimir
Publicado: (2019)

Management of Dental Extraction in a Female Patient with Fanconi Anemia
por: Peisker, Andre, et al.
Publicado: (2014)

Orthognathic Surgery with Interdisciplinary Digital Planning in Patients with Geroderma Osteodysplasticum: A Case Report
por: Tolksdorf, Konrad, et al.
Publicado: (2023)

Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis
por: Hilpert, Jan, et al.
Publicado: (2023)

Gender and risk‐taking behaviors influence the clinical presentation of oral squamous cell carcinoma
por: Wolfer, Susanne, et al.
Publicado: (2022)

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [(18)F]FEDAA1106
por: Takano, Akihiro, et al.
Publicado: (2013)

Early Mortality among Patients with Head and Neck Cancer Diagnosed in Thuringia, Germany, between 1996 and 2016—A Population-Based Study
por: Kouka, Mussab, et al.
Publicado: (2022)

Longterm quality of life after oncologic surgery and microvascular free flap reconstruction in patients with oral squamous cell carcinoma
por: Peisker, Andre, et al.
Publicado: (2016)

Bayes and empirical Bayes methods for data analysis /
por: Carlin, Bradley P.
Publicado: (2000)

Bayes and empirical Bayes methods for data analysis
por: Carlin, Bradley P.
Publicado: (1998)

Progesterone Hypersensitivity Induced by Exogenous Progesterone Exposure
por: Dhaliwal, Gurnoor, et al.
Publicado: (2023)

Think Bayes
por: Downey, Allen
Publicado: (2013)

Think Bayes
por: Downey, Allen
Publicado: (2013)

Bayes theory
por: Hartigan, John A., 1937-
Publicado: (1983)

DNA by the Bay
por: Strange, Carolyn J.
Publicado: (1996)

Bayes and discovery
por: Bernardo, Jose
Publicado: (2011)

Supersymmetry at bay?
por: Baer, Howard W, et al.
Publicado: (1985)

Bayes theory
por: Hartigan, J A
Publicado: (1983)

Think Bayes
por: Downey, Allen
Publicado: (2021)

Bay Leaf
por: Batool, Saima, et al.
Publicado: (2020)

Screening and Early Diagnosis in Gynecological Cancers
por: Giannella, Luca, et al.
Publicado: (2023)

Bargaining theory and fairness: a theoretical and experimental approach considering freedom of choice and the crowding-out of intrinsic motivation
por: Crüger, Arwed
Publicado: (2015)

Progesterone and progestogens
por: Lipinski, Joanne
Publicado: (2022)

Diagnosis of Appendiceal Neuroendocrine Tumors Following Incidental Appendectomy During Benign Gynecologic Laparoscopic Surgeries: A Case Series
por: Altshuler, Paulina C, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k2sbmvitl920fifrt4m8pnjg7g