Leptin – a slimmer’s dream that crashed?

The hopes of millions of obese persons were raised in 1994 when the “fat-melting” hormone leptin was discovered by Friedman and colleagues. Primary experiments on the adipose-tissue-derived hormone leptin seemed very promising and gave new life to obesity research. Drug companies also weathered prof...

Descripción completa

Detalles Bibliográficos
Autor principal: Karlsson, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2000
Materias:
Discussion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282603/
https://www.ncbi.nlm.nih.gov/pubmed/30532682
_version_ 1783379029893578752
author Karlsson, Cecilia
author_facet Karlsson, Cecilia
author_sort Karlsson, Cecilia
collection PubMed
description The hopes of millions of obese persons were raised in 1994 when the “fat-melting” hormone leptin was discovered by Friedman and colleagues. Primary experiments on the adipose-tissue-derived hormone leptin seemed very promising and gave new life to obesity research. Drug companies also weathered profit and the human version of leptin was licensed to the biotech firm Amgen Inc. for an initial fee of $20 million. But is leptin the drug obese individuals have long waited for or is it just an illusion? This review will try to summarise current data on the role of leptin in body weight regulation.
format Online
Article
Text
id pubmed-6282603
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher The Communications and Publications Division (CPD) of the IFCC
record_format MEDLINE/PubMed
spelling pubmed-62826032018-12-07 Leptin – a slimmer’s dream that crashed? Karlsson, Cecilia EJIFCC Discussion The hopes of millions of obese persons were raised in 1994 when the “fat-melting” hormone leptin was discovered by Friedman and colleagues. Primary experiments on the adipose-tissue-derived hormone leptin seemed very promising and gave new life to obesity research. Drug companies also weathered profit and the human version of leptin was licensed to the biotech firm Amgen Inc. for an initial fee of $20 million. But is leptin the drug obese individuals have long waited for or is it just an illusion? This review will try to summarise current data on the role of leptin in body weight regulation. The Communications and Publications Division (CPD) of the IFCC 2000-09-01 /pmc/articles/PMC6282603/ /pubmed/30532682 Text en Copyright © 2000 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discussion
Karlsson, Cecilia
Leptin – a slimmer’s dream that crashed?
title Leptin – a slimmer’s dream that crashed?
title_full Leptin – a slimmer’s dream that crashed?
title_fullStr Leptin – a slimmer’s dream that crashed?
title_full_unstemmed Leptin – a slimmer’s dream that crashed?
title_short Leptin – a slimmer’s dream that crashed?
title_sort leptin – a slimmer’s dream that crashed?
topic Discussion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282603/
https://www.ncbi.nlm.nih.gov/pubmed/30532682
work_keys_str_mv AT karlssoncecilia leptinaslimmersdreamthatcrashed

Ejemplares similares