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Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report

Proflavine is an acridine dye used with high‐resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short‐term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective ana...

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Autores principales: Pantano, Naitielle, Hunt, Brady, Schwarz, Richard A., Parra, Sonia, Cherry, Katelin, Possati‐Resende, Júlio César, Longatto‐Filho, Adhemar, Fregnani, José Humberto Tavares Guerreiro, Castle, Philip E., Schmeler, Kathleen, Richards‐Kortum, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282608/
https://www.ncbi.nlm.nih.gov/pubmed/29981148
http://dx.doi.org/10.1111/php.12976
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author Pantano, Naitielle
Hunt, Brady
Schwarz, Richard A.
Parra, Sonia
Cherry, Katelin
Possati‐Resende, Júlio César
Longatto‐Filho, Adhemar
Fregnani, José Humberto Tavares Guerreiro
Castle, Philip E.
Schmeler, Kathleen
Richards‐Kortum, Rebecca
author_facet Pantano, Naitielle
Hunt, Brady
Schwarz, Richard A.
Parra, Sonia
Cherry, Katelin
Possati‐Resende, Júlio César
Longatto‐Filho, Adhemar
Fregnani, José Humberto Tavares Guerreiro
Castle, Philip E.
Schmeler, Kathleen
Richards‐Kortum, Rebecca
author_sort Pantano, Naitielle
collection PubMed
description Proflavine is an acridine dye used with high‐resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short‐term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow‐up based on histopathologic results and per the local standards of care. Progression of disease was evaluated by comparing histopathology from the initial visit to the worst subsequent histopathology result from all follow‐up visits. Mean duration of follow‐up was 18.7 and 20.1 months for the proflavine‐exposed and controls groups, respectively. There were no significant differences in disease progression from normal/CIN1 to CIN2/3 or from any initial diagnosis to invasive cancer between the proflavine exposed and control groups overall. Risks of cervical dysplasia progression observed in this study are in agreement with those of the natural history of cervical cancer. Our results suggest that cervical exposure to dilute proflavine does not increase the risk of cervical precancer and cancer.
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spelling pubmed-62826082018-12-11 Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report Pantano, Naitielle Hunt, Brady Schwarz, Richard A. Parra, Sonia Cherry, Katelin Possati‐Resende, Júlio César Longatto‐Filho, Adhemar Fregnani, José Humberto Tavares Guerreiro Castle, Philip E. Schmeler, Kathleen Richards‐Kortum, Rebecca Photochem Photobiol Research Note Proflavine is an acridine dye used with high‐resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short‐term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow‐up based on histopathologic results and per the local standards of care. Progression of disease was evaluated by comparing histopathology from the initial visit to the worst subsequent histopathology result from all follow‐up visits. Mean duration of follow‐up was 18.7 and 20.1 months for the proflavine‐exposed and controls groups, respectively. There were no significant differences in disease progression from normal/CIN1 to CIN2/3 or from any initial diagnosis to invasive cancer between the proflavine exposed and control groups overall. Risks of cervical dysplasia progression observed in this study are in agreement with those of the natural history of cervical cancer. Our results suggest that cervical exposure to dilute proflavine does not increase the risk of cervical precancer and cancer. John Wiley and Sons Inc. 2018-07-31 2018 /pmc/articles/PMC6282608/ /pubmed/29981148 http://dx.doi.org/10.1111/php.12976 Text en © 2018 The Authors. Photochemistry and Photobiology published by Wiley Periodicals, Inc. on behalf of American Society for Photobiology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Pantano, Naitielle
Hunt, Brady
Schwarz, Richard A.
Parra, Sonia
Cherry, Katelin
Possati‐Resende, Júlio César
Longatto‐Filho, Adhemar
Fregnani, José Humberto Tavares Guerreiro
Castle, Philip E.
Schmeler, Kathleen
Richards‐Kortum, Rebecca
Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
title Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
title_full Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
title_fullStr Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
title_full_unstemmed Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
title_short Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
title_sort is proflavine exposure associated with disease progression in women with cervical dysplasia? a brief report
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282608/
https://www.ncbi.nlm.nih.gov/pubmed/29981148
http://dx.doi.org/10.1111/php.12976
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