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Cytochrome P450 3A Induction Predicts P‐glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine

Rifampin demonstrated dose‐dependent relative induction between cytochrome P (CYP)3A and P‐glycoprotein (P‐gp), organic anion transporting polypeptides (OATPs), or CYP2C9; P‐gp, OATP, and CYP2C9 induction was one drug–drug interaction (DDI) category lower than that observed for CYP3A across a wide r...

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Detalles Bibliográficos
Autores principales:	Lutz, Justin D., Kirby, Brian J., Wang, Lu, Song, Qinghua, Ling, John, Massetto, Benedetta, Worth, Angela, Kearney, Brian P., Mathias, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282692/ https://www.ncbi.nlm.nih.gov/pubmed/29569712 http://dx.doi.org/10.1002/cpt.1072

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