Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood–brain barrier model

OBJECTIVE: Nuclear receptors and cytochrome P450 (CYP) regulate hepatic metabolism of several drugs. Nuclear receptors are expressed at the neurovascular unit of patients with drug‐resistant epilepsy. We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain en...

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Detalles Bibliográficos
Autores principales: Ghosh, Chaitali, Hossain, Mohammed, Mishra, Saurabh, Khan, Sameena, Gonzalez‐Martinez, Jorge, Marchi, Nicola, Janigro, Damir, Bingaman, William, Najm, Imad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282717/
https://www.ncbi.nlm.nih.gov/pubmed/30264400
http://dx.doi.org/10.1111/epi.14567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282717/
https://www.ncbi.nlm.nih.gov/pubmed/30264400
http://dx.doi.org/10.1111/epi.14567

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