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Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations decreases over time in blood, suggesting selection against the mutation. How...

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Detalles Bibliográficos
Autores principales:	Su, Tianhong, Grady, John P, Afshar, Sorena, McDonald, Stuart AC, Taylor, Robert W, Turnbull, Doug M, Greaves, Laura C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2018
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282723/ https://www.ncbi.nlm.nih.gov/pubmed/30146801 http://dx.doi.org/10.1002/path.5156

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