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Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)

AIM: Recently we have observed differences in the ability of metformin and AICAR to repress glucose production from hepatocytes using 8CPT‐cAMP. Previous results indicate that, in addition to activating protein kinase A, 8CPT‐modified cAMP analogues suppress the nitrobenzylthioinosine (NBMPR)‐sensit...

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Detalles Bibliográficos
Autores principales:	Logie, Lisa, Lees, Zoe, Allwood, J. William, McDougall, Gordon, Beall, Craig, Rena, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282725/ https://www.ncbi.nlm.nih.gov/pubmed/29962100 http://dx.doi.org/10.1111/dom.13455

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