The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis

In MS, B cells survive peripheral tolerance checkpoints to mediate local inflammation, but the underlying molecular mechanisms are relatively underexplored. In mice, the MIF pathway controls B‐cell development and the induction of EAE. Here, we found that MIF and MIF receptor CD74 are downregulated,...

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Detalles Bibliográficos
Autores principales: Rijvers, Liza, Melief, Marie‐José, van der Vuurst de Vries, Roos M., Stéphant, Maeva, van Langelaar, Jamie, Wierenga‐Wolf, Annet F., Hogervorst, Jeanet M., Geurts‐Moespot, Anneke J., Sweep, Fred C. G. J., Hintzen, Rogier Q., van Luijn, Marvin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Immunodeficiencies and autoimmunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282801/
https://www.ncbi.nlm.nih.gov/pubmed/30160778
http://dx.doi.org/10.1002/eji.201847623

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