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Neutrophil phenotypes in health and disease

Neutrophils are one of the most important effector cells of the innate immune response (1). They are traditionally seen as a homogenous population of short‐lived cells mainly involved in the defence against extracellular microorganisms by phagocytosis and intracellular killing (1,2). The cells conta...

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Autores principales: Hellebrekers, Pien, Vrisekoop, Nienke, Koenderman, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282827/
https://www.ncbi.nlm.nih.gov/pubmed/29682724
http://dx.doi.org/10.1111/eci.12943
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author Hellebrekers, Pien
Vrisekoop, Nienke
Koenderman, Leo
author_facet Hellebrekers, Pien
Vrisekoop, Nienke
Koenderman, Leo
author_sort Hellebrekers, Pien
collection PubMed
description Neutrophils are one of the most important effector cells of the innate immune response (1). They are traditionally seen as a homogenous population of short‐lived cells mainly involved in the defence against extracellular microorganisms by phagocytosis and intracellular killing (1,2). The cells contain a large armamentarium that aids in this function and ranges from the production of reactive oxygen species by a membrane‐bound NADPH oxidase to cytotoxic proteins and peptides residing in the different granules present in the cytoplasm (3). Recently, the view of neutrophils belonging to a homogenous population of cells has been challenged, and several neutrophil phenotypes have been described that exhibit specialized functions, such as involvement in tissue repair, tumour killing and immune regulation (4). It is not clear whether these cells belong to separate parallel lineages originating from the bone marrow or that neutrophils become instructed in the distant tissues, thus changing their phenotypes. In addition, functional heterogeneity in a phenotypically homogenous population of neutrophils adds to the complexity of neutrophil phenotypes(5). This article will review the current literature describing the heterogeneity within the neutrophil compartment with respect to both phenotype and function in health and disease.
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spelling pubmed-62828272018-12-11 Neutrophil phenotypes in health and disease Hellebrekers, Pien Vrisekoop, Nienke Koenderman, Leo Eur J Clin Invest Neutrophils. Guest Editor: Dirk Roos Neutrophils are one of the most important effector cells of the innate immune response (1). They are traditionally seen as a homogenous population of short‐lived cells mainly involved in the defence against extracellular microorganisms by phagocytosis and intracellular killing (1,2). The cells contain a large armamentarium that aids in this function and ranges from the production of reactive oxygen species by a membrane‐bound NADPH oxidase to cytotoxic proteins and peptides residing in the different granules present in the cytoplasm (3). Recently, the view of neutrophils belonging to a homogenous population of cells has been challenged, and several neutrophil phenotypes have been described that exhibit specialized functions, such as involvement in tissue repair, tumour killing and immune regulation (4). It is not clear whether these cells belong to separate parallel lineages originating from the bone marrow or that neutrophils become instructed in the distant tissues, thus changing their phenotypes. In addition, functional heterogeneity in a phenotypically homogenous population of neutrophils adds to the complexity of neutrophil phenotypes(5). This article will review the current literature describing the heterogeneity within the neutrophil compartment with respect to both phenotype and function in health and disease. John Wiley and Sons Inc. 2018-05-25 2018-11 /pmc/articles/PMC6282827/ /pubmed/29682724 http://dx.doi.org/10.1111/eci.12943 Text en © 2018 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Neutrophils. Guest Editor: Dirk Roos
Hellebrekers, Pien
Vrisekoop, Nienke
Koenderman, Leo
Neutrophil phenotypes in health and disease
title Neutrophil phenotypes in health and disease
title_full Neutrophil phenotypes in health and disease
title_fullStr Neutrophil phenotypes in health and disease
title_full_unstemmed Neutrophil phenotypes in health and disease
title_short Neutrophil phenotypes in health and disease
title_sort neutrophil phenotypes in health and disease
topic Neutrophils. Guest Editor: Dirk Roos
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282827/
https://www.ncbi.nlm.nih.gov/pubmed/29682724
http://dx.doi.org/10.1111/eci.12943
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