Cargando…
Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with cognitive deficit but the exact neural mechanisms remain unclear. PURPOSE: To explore sequential brain activities using functional magnetic resonance imaging (fMRI) during the performance of a decision‐making task, and to determine wh...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282848/ https://www.ncbi.nlm.nih.gov/pubmed/29537670 http://dx.doi.org/10.1002/jmri.26006 |
_version_ | 1783379078149046272 |
---|---|
author | Wu, Bei‐Bei Ma, Ye Xie, Lei Huang, Jin‐Zhuang Sun, Zong‐Bo Hou, Zhi‐Duo Guo, Rui‐Wei Lin, Zhi‐Rong Duan, Shou‐Xing Zhao, Shan‐Shan Yao‐Xie, Sun, Dan‐Miao Zhu, Chun‐Min Ma, Shu‐Hua |
author_facet | Wu, Bei‐Bei Ma, Ye Xie, Lei Huang, Jin‐Zhuang Sun, Zong‐Bo Hou, Zhi‐Duo Guo, Rui‐Wei Lin, Zhi‐Rong Duan, Shou‐Xing Zhao, Shan‐Shan Yao‐Xie, Sun, Dan‐Miao Zhu, Chun‐Min Ma, Shu‐Hua |
author_sort | Wu, Bei‐Bei |
collection | PubMed |
description | BACKGROUND: Systemic lupus erythematosus (SLE) is associated with cognitive deficit but the exact neural mechanisms remain unclear. PURPOSE: To explore sequential brain activities using functional magnetic resonance imaging (fMRI) during the performance of a decision‐making task, and to determine whether serum or clinical markers can reflect the involvement of the brain in SLE. SUBJECTS: Sixteen female SLE patients without overt clinical neuropsychiatric symptoms and 16 healthy controls were included. FIELD STRENGTH/SEQUENCE: 1.5T, T(1)‐weighted anatomic images, gradient‐echo echo‐planar imaging sequence, and 3D images. ASSESSMENT: The computer‐based Iowa Gambling Task (IGT) for assessing decision‐making was performed by SLE patients and 16 matched controls; brain activity was recorded via blood oxygen level‐dependent (BOLD) fMRI. The amplitudes of the average BOLD responses were calculated for each individual subject, and activation data from fMRI experiments were compared between the two groups. STATISTICAL TESTS: Two‐sample t‐test; repeated‐measures analysis of variance (ANOVA); linear regression analyses. RESULTS: Imaging revealed activity in a distributed network of brain regions in both groups, including the ventromedial prefrontal cortex (vmPFC), the orbitofrontal cortex (OFC), the dorsolateral prefrontal cortex (dlPFC), the anterior cingulate cortex (ACC), the posterior cingulate cortex (PCC), and the striatum, as well as the insular, parietal, and occipital cortices. Compared to controls, SLE patients showed lower activation in a convergence zone and the limbic system, namely, the OFC, vmPFC, ACC, and PCC, but greater activation in memory, emotion, and behavior systems involving the dlPFC, the insular cortex and the striatum. Furthermore, brain activation in the vmPFC was positively correlated with IGT scores (r = 0.63, P < 0.001), but inversely related to disease activity (r = −0.57, P < 0.01). DATA CONCLUSION: The dynamics among the aforementioned neural systems (some hyperfunctioning, others hypofunctioning) may shed some light on the pathologic mechanisms underlying SLE without overt clinical neuropsychiatric symptoms. In addition, disease activity may potentially be used as an effective biomarker reflecting cerebral involvement in SLE. Level of Evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1508–1517 |
format | Online Article Text |
id | pubmed-6282848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62828482018-12-11 Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus Wu, Bei‐Bei Ma, Ye Xie, Lei Huang, Jin‐Zhuang Sun, Zong‐Bo Hou, Zhi‐Duo Guo, Rui‐Wei Lin, Zhi‐Rong Duan, Shou‐Xing Zhao, Shan‐Shan Yao‐Xie, Sun, Dan‐Miao Zhu, Chun‐Min Ma, Shu‐Hua J Magn Reson Imaging Original Research BACKGROUND: Systemic lupus erythematosus (SLE) is associated with cognitive deficit but the exact neural mechanisms remain unclear. PURPOSE: To explore sequential brain activities using functional magnetic resonance imaging (fMRI) during the performance of a decision‐making task, and to determine whether serum or clinical markers can reflect the involvement of the brain in SLE. SUBJECTS: Sixteen female SLE patients without overt clinical neuropsychiatric symptoms and 16 healthy controls were included. FIELD STRENGTH/SEQUENCE: 1.5T, T(1)‐weighted anatomic images, gradient‐echo echo‐planar imaging sequence, and 3D images. ASSESSMENT: The computer‐based Iowa Gambling Task (IGT) for assessing decision‐making was performed by SLE patients and 16 matched controls; brain activity was recorded via blood oxygen level‐dependent (BOLD) fMRI. The amplitudes of the average BOLD responses were calculated for each individual subject, and activation data from fMRI experiments were compared between the two groups. STATISTICAL TESTS: Two‐sample t‐test; repeated‐measures analysis of variance (ANOVA); linear regression analyses. RESULTS: Imaging revealed activity in a distributed network of brain regions in both groups, including the ventromedial prefrontal cortex (vmPFC), the orbitofrontal cortex (OFC), the dorsolateral prefrontal cortex (dlPFC), the anterior cingulate cortex (ACC), the posterior cingulate cortex (PCC), and the striatum, as well as the insular, parietal, and occipital cortices. Compared to controls, SLE patients showed lower activation in a convergence zone and the limbic system, namely, the OFC, vmPFC, ACC, and PCC, but greater activation in memory, emotion, and behavior systems involving the dlPFC, the insular cortex and the striatum. Furthermore, brain activation in the vmPFC was positively correlated with IGT scores (r = 0.63, P < 0.001), but inversely related to disease activity (r = −0.57, P < 0.01). DATA CONCLUSION: The dynamics among the aforementioned neural systems (some hyperfunctioning, others hypofunctioning) may shed some light on the pathologic mechanisms underlying SLE without overt clinical neuropsychiatric symptoms. In addition, disease activity may potentially be used as an effective biomarker reflecting cerebral involvement in SLE. Level of Evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1508–1517 John Wiley and Sons Inc. 2018-03-14 2018-12 /pmc/articles/PMC6282848/ /pubmed/29537670 http://dx.doi.org/10.1002/jmri.26006 Text en © 2018 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Wu, Bei‐Bei Ma, Ye Xie, Lei Huang, Jin‐Zhuang Sun, Zong‐Bo Hou, Zhi‐Duo Guo, Rui‐Wei Lin, Zhi‐Rong Duan, Shou‐Xing Zhao, Shan‐Shan Yao‐Xie, Sun, Dan‐Miao Zhu, Chun‐Min Ma, Shu‐Hua Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
title | Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
title_full | Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
title_fullStr | Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
title_full_unstemmed | Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
title_short | Impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
title_sort | impaired decision‐making and functional neuronal network activity in systemic lupus erythematosus |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282848/ https://www.ncbi.nlm.nih.gov/pubmed/29537670 http://dx.doi.org/10.1002/jmri.26006 |
work_keys_str_mv | AT wubeibei impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT maye impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT xielei impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT huangjinzhuang impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT sunzongbo impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT houzhiduo impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT guoruiwei impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT linzhirong impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT duanshouxing impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT zhaoshanshan impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT yaoxie impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT sundanmiao impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT zhuchunmin impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus AT mashuhua impaireddecisionmakingandfunctionalneuronalnetworkactivityinsystemiclupuserythematosus |