Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium‐Functionalized Microdevices

SN‐38, the active metabolite of irinotecan, is released upon liver hydrolysis to mediate potent antitumor activity. Systemic exposure to SN‐38, however, also leads to serious side effects. To reduce systemic toxicity by controlling where and when SN‐38 is generated, a new prodrug was specifically de...

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Detalles Bibliográficos
Autores principales: Adam, Catherine, Pérez‐López, Ana M., Hamilton, Lloyd, Rubio‐Ruiz, Belén, Bray, Thomas L., Sieger, Dirk, Brennan, Paul M., Unciti‐Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282958/
https://www.ncbi.nlm.nih.gov/pubmed/30187973
http://dx.doi.org/10.1002/chem.201803725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282958/
https://www.ncbi.nlm.nih.gov/pubmed/30187973
http://dx.doi.org/10.1002/chem.201803725

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