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Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system
Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283023/ https://www.ncbi.nlm.nih.gov/pubmed/29921411 http://dx.doi.org/10.5483/BMBRep.2018.51.11.056 |
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author | Kim, Soo-Min Hwang, Kyung-A Choi, Kyung-Chul |
author_facet | Kim, Soo-Min Hwang, Kyung-A Choi, Kyung-Chul |
author_sort | Kim, Soo-Min |
collection | PubMed |
description | Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately by reprogramming cancer cell metabolism. This review provides up to date findings regarding the roles of ROS generation induced by diverse biological molecules and chemicals in representative women’s cancer. Specifically, we describe the cellular signaling pathways that regulate direct or indirect interactions between ROS homeostasis and metabolism within female genital cancer cells. |
format | Online Article Text |
id | pubmed-6283023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-62830232018-12-18 Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system Kim, Soo-Min Hwang, Kyung-A Choi, Kyung-Chul BMB Rep Contributed Mini Review Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately by reprogramming cancer cell metabolism. This review provides up to date findings regarding the roles of ROS generation induced by diverse biological molecules and chemicals in representative women’s cancer. Specifically, we describe the cellular signaling pathways that regulate direct or indirect interactions between ROS homeostasis and metabolism within female genital cancer cells. Korean Society for Biochemistry and Molecular Biology 2018-11 2018-11-30 /pmc/articles/PMC6283023/ /pubmed/29921411 http://dx.doi.org/10.5483/BMBRep.2018.51.11.056 Text en Copyright © 2018 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Contributed Mini Review Kim, Soo-Min Hwang, Kyung-A Choi, Kyung-Chul Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
title | Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
title_full | Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
title_fullStr | Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
title_full_unstemmed | Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
title_short | Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
title_sort | potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system |
topic | Contributed Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283023/ https://www.ncbi.nlm.nih.gov/pubmed/29921411 http://dx.doi.org/10.5483/BMBRep.2018.51.11.056 |
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