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An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor effects against melanoma

Recent studies showed that the PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma by enhancing antitumor immune activity. Currently, major strategies for the PD-1/PD-L1 blockade have mainly focused on the use of antibodies and compounds. Seeking an alternative approach, others employ...

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Detalles Bibliográficos
Autores principales: Wei, Mulan, Liu, Xujie, Cao, Chunyu, Yang, Jianlin, Lv, Yafeng, Huang, Jiaojiao, Wang, Yanlin, Qin, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283027/
https://www.ncbi.nlm.nih.gov/pubmed/30021673
http://dx.doi.org/10.5483/BMBRep.2018.51.11.076