Role of SH2B3 R262W gene polymorphism and risk of coronary heart disease: A PRISMA-compliant meta-analysis

BACKGROUND: More susceptibility genes have been proved to be associated with coronary heart disease (CHD). The goal of our study is to evaluate the association between the R262W polymorphism of SH2B3 gene and risk of CHD. METHODS: A systematic search was conducted using PubMed, Embase, Web of Science, CNKI, and WanFang databases up to March of 2018. The data of individual study were individually performed by 2 reviewers. The meta-analysis was performed by Stata software and expressed by the pooled odds ratio (OR) and the 95% confidence interval (CI), which were calculated by specific model according to heterogeneity. RESULTS: Our research was based on 12 studies involving 25,845 patients and 68,910 healthy controls. Significant association between the variant R262W and CHD were found in overall populations (OR = 1.12, 95%CI = 1.09–1.15, P = .389, I(2) = 5.4%), but not found in Asian (OR = 1.05, 95%CI = 0.98–1.12, I(2) = 0.0%) in subgroup analysis by ethnicity. In another subgroup analysis, when classified into CHD and myocardial infarction (MI), there was a significance association between R262W and CHD (OR = 1.11,95% CI = 1.07–1.15, I(2) = 13.5%) and MI (OR = 1.13, 95%CI = 1.08–1.18, I(2) = 0.0%). The Begg's funnel plot revealed no significant publication bias. CONCLUSIONS: The R262W polymorphism is associated with risk of CHD or MI in Europeans, but not in Asians.