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STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure
This study aims to investigate the gastrointestinal functions of patients with liver failure (LF) based on gastrointestinal dysfunction (GD) scores and serum gastrointestinal hormone levels. The GD in LF patients was scored using the gastrointestinal dysfunction scoring criteria. Serum gastrin (GAS)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283146/ https://www.ncbi.nlm.nih.gov/pubmed/30508896 http://dx.doi.org/10.1097/MD.0000000000013167 |
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author | Wang, Ping Zhang, Ying-Jian Li, Yi-Ran Xia, Xiao-Yan Lv, Shu-Yan |
author_facet | Wang, Ping Zhang, Ying-Jian Li, Yi-Ran Xia, Xiao-Yan Lv, Shu-Yan |
author_sort | Wang, Ping |
collection | PubMed |
description | This study aims to investigate the gastrointestinal functions of patients with liver failure (LF) based on gastrointestinal dysfunction (GD) scores and serum gastrointestinal hormone levels. The GD in LF patients was scored using the gastrointestinal dysfunction scoring criteria. Serum gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) levels were determined in LF patients. In addition, liver function and prothrombin activity were detected, and ultrasonography was performed. The GD score was significantly higher in the LF groups than in the control group. Compared with the control group, serum GAS, CCK, and MTL levels significantly increased in the LF groups, and was positively correlated with the severity of LF. Furthermore, in the LF groups, GD was positively correlated with the severity of LF. However, the GD score and serum GAS, CCK, and MTL levels in the acute LF group were not statistically different, when compared with those in the subacute LF group, acute-on-chronic LF group and chronic LF group. LF plays a key role in the development of GD, and may be the main cause of obvious gastrointestinal symptoms, such as abdominal distension, nausea, vomiting and anorexia, in LF patients. The severity of GD is not associated with LF type, but is positively correlated with the severity of LF, suggesting that GD in LF patients may have complicated mechanisms. |
format | Online Article Text |
id | pubmed-6283146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-62831462018-12-26 STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure Wang, Ping Zhang, Ying-Jian Li, Yi-Ran Xia, Xiao-Yan Lv, Shu-Yan Medicine (Baltimore) Research Article This study aims to investigate the gastrointestinal functions of patients with liver failure (LF) based on gastrointestinal dysfunction (GD) scores and serum gastrointestinal hormone levels. The GD in LF patients was scored using the gastrointestinal dysfunction scoring criteria. Serum gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) levels were determined in LF patients. In addition, liver function and prothrombin activity were detected, and ultrasonography was performed. The GD score was significantly higher in the LF groups than in the control group. Compared with the control group, serum GAS, CCK, and MTL levels significantly increased in the LF groups, and was positively correlated with the severity of LF. Furthermore, in the LF groups, GD was positively correlated with the severity of LF. However, the GD score and serum GAS, CCK, and MTL levels in the acute LF group were not statistically different, when compared with those in the subacute LF group, acute-on-chronic LF group and chronic LF group. LF plays a key role in the development of GD, and may be the main cause of obvious gastrointestinal symptoms, such as abdominal distension, nausea, vomiting and anorexia, in LF patients. The severity of GD is not associated with LF type, but is positively correlated with the severity of LF, suggesting that GD in LF patients may have complicated mechanisms. Wolters Kluwer Health 2018-11-30 /pmc/articles/PMC6283146/ /pubmed/30508896 http://dx.doi.org/10.1097/MD.0000000000013167 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Wang, Ping Zhang, Ying-Jian Li, Yi-Ran Xia, Xiao-Yan Lv, Shu-Yan STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
title | STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
title_full | STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
title_fullStr | STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
title_full_unstemmed | STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
title_short | STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
title_sort | store-gastrointestinal functions and gastrointestinal hormones in patients with liver failure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283146/ https://www.ncbi.nlm.nih.gov/pubmed/30508896 http://dx.doi.org/10.1097/MD.0000000000013167 |
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