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Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis
BACKGROUND: Acute perioperative hypertension has been associated with poor outcomes of surgery, and the role of calcium channel blockers (CCB) on controlling perioperative blood pressure (BP) remains controversial. Thus, this meta-analysis was designed to assess the efficacy and safety of CCB in tre...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer Health
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283187/ https://www.ncbi.nlm.nih.gov/pubmed/30508892 http://dx.doi.org/10.1097/MD.0000000000013152 |
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author | Lin, Yu Ma, Lina |
author_facet | Lin, Yu Ma, Lina |
author_sort | Lin, Yu |
collection | PubMed |
description | BACKGROUND: Acute perioperative hypertension has been associated with poor outcomes of surgery, and the role of calcium channel blockers (CCB) on controlling perioperative blood pressure (BP) remains controversial. Thus, this meta-analysis was designed to assess the efficacy and safety of CCB in treating perioperative hypertension compared with other antihypertensive agents. METHODS: PubMed, Medline, Cochrane, and EMABSE databases was systematically searched up to January 2018 for randomized control trials (RCTs) or other control studies comparing the efficacy of CCB versus other antihypertensive medicines for perioperative hypertension modulation. The efficacy and safety of CCB in treating perioperative hypertension were assessed through pooling mean difference (MD) with its 95% confidence interval (CI) or risk ratio (RR) with its 95% CI. RESULTS: In total, 14 studies were included in the meta-analysis. There is no significant difference regarding successful treatment (RR = 2.64, 95% CI: 0.95, 7.29; I(2) = 97%, P <.05), systolic blood pressure (SBP) (MD = −7.05, 95% CI: −16.27, 2.17; I(2) = 78%, P <.05), overall adverse events (RR = 0.88, 95% CI: 0.66, 1.16; I(2) = 54%, P = .02), atrial fibrillation (RR = 0.80, 95% CI: 0.60, 1.07; I(2) = 32%, P = .20) and heart rates (MD = −1.05, 95% CI: −7.81, 5.71; I(2) = 84%, P < .05) between patients treated by CCB and other drugs. In the subgroup analysis, statistical significance can be observed regarding successful treatment (RR = 3.46, 95%CI: 1.67, 7.18; I(2) = 84%, P <.05) and postoperative SBP (MD = −9.98, 95%CI: −20.03, 0.08; I(2) = 97%, P <.05) in the RCTs subgroup. CONCLUSION: CCB was highly effective and well tolerated for treating perioperative hypertension. |
format | Online Article Text |
id | pubmed-6283187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-62831872018-12-26 Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis Lin, Yu Ma, Lina Medicine (Baltimore) Research Article BACKGROUND: Acute perioperative hypertension has been associated with poor outcomes of surgery, and the role of calcium channel blockers (CCB) on controlling perioperative blood pressure (BP) remains controversial. Thus, this meta-analysis was designed to assess the efficacy and safety of CCB in treating perioperative hypertension compared with other antihypertensive agents. METHODS: PubMed, Medline, Cochrane, and EMABSE databases was systematically searched up to January 2018 for randomized control trials (RCTs) or other control studies comparing the efficacy of CCB versus other antihypertensive medicines for perioperative hypertension modulation. The efficacy and safety of CCB in treating perioperative hypertension were assessed through pooling mean difference (MD) with its 95% confidence interval (CI) or risk ratio (RR) with its 95% CI. RESULTS: In total, 14 studies were included in the meta-analysis. There is no significant difference regarding successful treatment (RR = 2.64, 95% CI: 0.95, 7.29; I(2) = 97%, P <.05), systolic blood pressure (SBP) (MD = −7.05, 95% CI: −16.27, 2.17; I(2) = 78%, P <.05), overall adverse events (RR = 0.88, 95% CI: 0.66, 1.16; I(2) = 54%, P = .02), atrial fibrillation (RR = 0.80, 95% CI: 0.60, 1.07; I(2) = 32%, P = .20) and heart rates (MD = −1.05, 95% CI: −7.81, 5.71; I(2) = 84%, P < .05) between patients treated by CCB and other drugs. In the subgroup analysis, statistical significance can be observed regarding successful treatment (RR = 3.46, 95%CI: 1.67, 7.18; I(2) = 84%, P <.05) and postoperative SBP (MD = −9.98, 95%CI: −20.03, 0.08; I(2) = 97%, P <.05) in the RCTs subgroup. CONCLUSION: CCB was highly effective and well tolerated for treating perioperative hypertension. Wolters Kluwer Health 2018-11-30 /pmc/articles/PMC6283187/ /pubmed/30508892 http://dx.doi.org/10.1097/MD.0000000000013152 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Research Article Lin, Yu Ma, Lina Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis |
title | Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis |
title_full | Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis |
title_fullStr | Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis |
title_full_unstemmed | Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis |
title_short | Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis |
title_sort | blood pressure lowering effect of calcium channel blockers on perioperative hypertension: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283187/ https://www.ncbi.nlm.nih.gov/pubmed/30508892 http://dx.doi.org/10.1097/MD.0000000000013152 |
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