Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation*

Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates break repair with cell cycle progression. Here, we performed whole-cell q...

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Detalles Bibliográficos
Autores principales: Halim, Vincentius A., García-Santisteban, Iraia, Warmerdam, Daniel O., van den Broek, Bram, Heck, Albert J. R., Mohammed, Shabaz, Medema, René H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283304/
https://www.ncbi.nlm.nih.gov/pubmed/29438997
http://dx.doi.org/10.1074/mcp.RA118.000652

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