Cargando…

The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites

The multi-protein complex WRAD, formed by WDR5, RbBP5, Ash2L and Dpy30, binds to the MLL SET domain to stabilize the catalytically active conformation required for histone H3K4 methylation. In addition, the WRAD complex contributes to the targeting of the activated complex to specific sites on chrom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mittal, Anshumali, Hobor, Fruzsina, Zhang, Ying, Martin, Stephen R, Gamblin, Steven J, Ramos, Andres, Wilson, Jon R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283417/ https://www.ncbi.nlm.nih.gov/pubmed/29897600 http://dx.doi.org/10.1093/nar/gky199

Ejemplares similares

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties
por: Dagil, Robert, et al.
Publicado: (2019)

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation
por: Zhang, Pamela, et al.
Publicado: (2015)

Evolving Catalytic Properties of the MLL Family SET Domain
por: Zhang, Ying, et al.
Publicado: (2015)

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex
por: Han, Jianming, et al.
Publicado: (2019)

An Ash2L/RbBP5 Heterodimer Stimulates the MLL1 Methyltransferase Activity through Coordinated Substrate Interactions with the MLL1 SET Domain
por: Cao, Fang, et al.
Publicado: (2010)

Recognition of asymmetrically dimethylated arginine by TDRD3
por: Sikorsky, Tomas, et al.
Publicado: (2012)

Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell
por: Li, Dong, et al.
Publicado: (2016)

Structural insights into TDP-43 in nucleic-acid binding and domain interactions
por: Kuo, Pan-Hsien, et al.
Publicado: (2009)

Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis
por: Schultz‐Rogers, Laura E., et al.
Publicado: (2022)

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
por: Marušič, Maja, et al.
Publicado: (2012)

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale
por: Islam, Barira, et al.
Publicado: (2013)

Crystal structure of an Escherichia coli Hfq Core (residues 2–69)–DNA complex reveals multifunctional nucleic acid binding sites
por: Orans, Jillian, et al.
Publicado: (2020)

Conformational analysis of nucleic acids revisited: Curves+
por: Lavery, R., et al.
Publicado: (2009)

Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe
por: Cai, Qi, et al.
Publicado: (2006)

Selenium derivatization of nucleic acids for crystallography
por: Jiang, Jiansheng, et al.
Publicado: (2007)

Exploring conformational equilibria of a heterodimeric ABC transporter
por: Timachi, M Hadi, et al.
Publicado: (2017)

ACE-domain selectivity extends beyond direct interacting residues at the active site
por: Cozier, Gyles E., et al.
Publicado: (2020)

Loop dependence of the stability and dynamics of nucleic acid hairpins
por: Kuznetsov, Serguei V., et al.
Publicado: (2008)

The crystal structure of an ‘All Locked’ nucleic acid duplex
por: Eichert, André, et al.
Publicado: (2010)

Guanine base stacking in G-quadruplex nucleic acids
por: Lech, Christopher Jacques, et al.
Publicado: (2013)

Solution NMR Structure of the Ca(2+)-bound N-terminal Domain of CaBP7: A REGULATOR OF GOLGI TRAFFICKING
por: McCue, Hannah V., et al.
Publicado: (2012)

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets
por: Díaz-Moreno, Irene, et al.
Publicado: (2010)

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation
por: Schultz, Laura E., et al.
Publicado: (2018)

Electrostatic free energy landscapes for nucleic acid helix assembly
por: Tan, Zhi-Jie, et al.
Publicado: (2006)

Conformational transitions in human translin enable nucleic acid binding
por: Pérez-Cano, Laura, et al.
Publicado: (2013)

Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)
por: Russell, Bonnie L., et al.
Publicado: (2023)

Hypoxia-induced RBBP7 promotes esophagus cancer progression by inducing CDK4 expression: RBBP7 promotes esophagus cancer progression
por: Wang, Renfeng, et al.
Publicado: (2022)

Stretching and unzipping nucleic acid hairpins using a synthetic nanopore
por: Zhao, Q., et al.
Publicado: (2008)

Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1
por: Knott, Gavin J, et al.
Publicado: (2021)

The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes
por: Wegrecki, Marcin, et al.
Publicado: (2015)

Heterogeneous dynamics in DNA site discrimination by the structurally homologous DNA-binding domains of ETS-family transcription factors
por: He, Gaofei, et al.
Publicado: (2015)

Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK
por: Wang, Na, et al.
Publicado: (2019)

Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing
por: Plangger, Raphael, et al.
Publicado: (2019)

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1
por: Rappas, Mathieu, et al.
Publicado: (2011)

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
por: Tsuda, Kengo, et al.
Publicado: (2009)

The phosphate clamp: a small and independent motif for nucleic acid backbone recognition
por: Komeda, Seiji, et al.
Publicado: (2011)

A measure of bending in nucleic acids structures applied to A-tract DNA
por: Lankaš, F., et al.
Publicado: (2010)

The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS
por: Gosselin, Pauline, et al.
Publicado: (2011)

Structural diversity of target-specific homopyrimidine peptide nucleic acid–dsDNA complexes
por: Bentin, Thomas, et al.
Publicado: (2006)

Backbone-base inclination as a fundamental determinant of nucleic acid self- and cross-pairing
por: Pallan, Pradeep S., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_6otb45cn9h0but4pi8884iti40