Cargando…

A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote

Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic...

Descripción completa

Detalles Bibliográficos
Autores principales: Bravo Núñez, María Angélica, Lange, Jeffrey J., Zanders, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283613/
https://www.ncbi.nlm.nih.gov/pubmed/30475921
http://dx.doi.org/10.1371/journal.pgen.1007836
_version_ 1783379195226750976
author Bravo Núñez, María Angélica
Lange, Jeffrey J.
Zanders, Sarah E.
author_facet Bravo Núñez, María Angélica
Lange, Jeffrey J.
Zanders, Sarah E.
author_sort Bravo Núñez, María Angélica
collection PubMed
description Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic drivers in wild isolates. We discovered that wtf13 found in lab stocks is a meiotic driver. wtf13 kills spores that do not inherit it by generating both a diffusible poison and a spore-specific antidote. Additionally, we demonstrate that wtf13 is suppressed by another wtf gene, wtf18-2, that arose spontaneously in the lab and makes only an antidote. Wtf18-2 does not act indiscriminately to prevent spore destruction. Instead, it rescues only the spores that inherit wtf18-2. In this way, wtf18-2 selfishly gains a transmission advantage of its own while dampening the drive of wtf13. This establishes a novel paradigm for meiotic drive suppressors and provides insight into the mechanisms and evolution of drive systems.
format Online
Article
Text
id pubmed-6283613
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-62836132018-12-19 A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote Bravo Núñez, María Angélica Lange, Jeffrey J. Zanders, Sarah E. PLoS Genet Research Article Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic drivers in wild isolates. We discovered that wtf13 found in lab stocks is a meiotic driver. wtf13 kills spores that do not inherit it by generating both a diffusible poison and a spore-specific antidote. Additionally, we demonstrate that wtf13 is suppressed by another wtf gene, wtf18-2, that arose spontaneously in the lab and makes only an antidote. Wtf18-2 does not act indiscriminately to prevent spore destruction. Instead, it rescues only the spores that inherit wtf18-2. In this way, wtf18-2 selfishly gains a transmission advantage of its own while dampening the drive of wtf13. This establishes a novel paradigm for meiotic drive suppressors and provides insight into the mechanisms and evolution of drive systems. Public Library of Science 2018-11-26 /pmc/articles/PMC6283613/ /pubmed/30475921 http://dx.doi.org/10.1371/journal.pgen.1007836 Text en © 2018 Bravo Núñez et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bravo Núñez, María Angélica
Lange, Jeffrey J.
Zanders, Sarah E.
A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
title A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
title_full A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
title_fullStr A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
title_full_unstemmed A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
title_short A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
title_sort suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283613/
https://www.ncbi.nlm.nih.gov/pubmed/30475921
http://dx.doi.org/10.1371/journal.pgen.1007836
work_keys_str_mv AT bravonunezmariaangelica asuppressorofawtfpoisonantidotemeioticdriveractsviamimicryofthedriversantidote
AT langejeffreyj asuppressorofawtfpoisonantidotemeioticdriveractsviamimicryofthedriversantidote
AT zanderssarahe asuppressorofawtfpoisonantidotemeioticdriveractsviamimicryofthedriversantidote
AT bravonunezmariaangelica suppressorofawtfpoisonantidotemeioticdriveractsviamimicryofthedriversantidote
AT langejeffreyj suppressorofawtfpoisonantidotemeioticdriveractsviamimicryofthedriversantidote
AT zanderssarahe suppressorofawtfpoisonantidotemeioticdriveractsviamimicryofthedriversantidote