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A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote
Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283613/ https://www.ncbi.nlm.nih.gov/pubmed/30475921 http://dx.doi.org/10.1371/journal.pgen.1007836 |
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author | Bravo Núñez, María Angélica Lange, Jeffrey J. Zanders, Sarah E. |
author_facet | Bravo Núñez, María Angélica Lange, Jeffrey J. Zanders, Sarah E. |
author_sort | Bravo Núñez, María Angélica |
collection | PubMed |
description | Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic drivers in wild isolates. We discovered that wtf13 found in lab stocks is a meiotic driver. wtf13 kills spores that do not inherit it by generating both a diffusible poison and a spore-specific antidote. Additionally, we demonstrate that wtf13 is suppressed by another wtf gene, wtf18-2, that arose spontaneously in the lab and makes only an antidote. Wtf18-2 does not act indiscriminately to prevent spore destruction. Instead, it rescues only the spores that inherit wtf18-2. In this way, wtf18-2 selfishly gains a transmission advantage of its own while dampening the drive of wtf13. This establishes a novel paradigm for meiotic drive suppressors and provides insight into the mechanisms and evolution of drive systems. |
format | Online Article Text |
id | pubmed-6283613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62836132018-12-19 A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote Bravo Núñez, María Angélica Lange, Jeffrey J. Zanders, Sarah E. PLoS Genet Research Article Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve suppressors. Here we investigate the wtf gene family from Schizosaccharomyces pombe, previously shown to contain meiotic drivers in wild isolates. We discovered that wtf13 found in lab stocks is a meiotic driver. wtf13 kills spores that do not inherit it by generating both a diffusible poison and a spore-specific antidote. Additionally, we demonstrate that wtf13 is suppressed by another wtf gene, wtf18-2, that arose spontaneously in the lab and makes only an antidote. Wtf18-2 does not act indiscriminately to prevent spore destruction. Instead, it rescues only the spores that inherit wtf18-2. In this way, wtf18-2 selfishly gains a transmission advantage of its own while dampening the drive of wtf13. This establishes a novel paradigm for meiotic drive suppressors and provides insight into the mechanisms and evolution of drive systems. Public Library of Science 2018-11-26 /pmc/articles/PMC6283613/ /pubmed/30475921 http://dx.doi.org/10.1371/journal.pgen.1007836 Text en © 2018 Bravo Núñez et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bravo Núñez, María Angélica Lange, Jeffrey J. Zanders, Sarah E. A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
title | A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
title_full | A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
title_fullStr | A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
title_full_unstemmed | A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
title_short | A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
title_sort | suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283613/ https://www.ncbi.nlm.nih.gov/pubmed/30475921 http://dx.doi.org/10.1371/journal.pgen.1007836 |
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