STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of...

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Detalles Bibliográficos
Autores principales: Benmerzoug, Sulayman, Rose, Stéphanie, Bounab, Badreddine, Gosset, David, Duneau, Laure, Chenuet, Pauline, Mollet, Lucile, Le Bert, Marc, Lambers, Christopher, Geleff, Silvana, Roth, Michael, Fauconnier, Louis, Sedda, Delphine, Carvalho, Clarisse, Perche, Olivier, Laurenceau, David, Ryffel, Bernhard, Apetoh, Lionel, Kiziltunc, Ahmet, Uslu, Hakan, Albez, Fadime Sultan, Akgun, Metin, Togbe, Dieudonnée, Quesniaux, Valerie F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283886/
https://www.ncbi.nlm.nih.gov/pubmed/30523277
http://dx.doi.org/10.1038/s41467-018-07425-1

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