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Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis

Multidrug-resistant tuberculosis (TB), defined as TB resistant to the two first-line drugs, isoniazid and rifampin, is a serious challenge to global TB eradication efforts. Although mutations in rpoA or rpoC have been proposed to compensate for this fitness cost due to rpoB mutation in rifampicin-re...

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Detalles Bibliográficos
Autores principales:	Xu, Zhihong, Zhou, Aiping, Wu, Jiawei, Zhou, Aiwu, Li, Jun, Zhang, Shulin, Wu, Wenjuan, Karakousis, Petros C., Yao, Yu-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283890/ https://www.ncbi.nlm.nih.gov/pubmed/30555440 http://dx.doi.org/10.3389/fmicb.2018.02895

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