Cargando…

Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation

Notch hyperactivation dominates T-cell acute lymphoblastic leukemia development, but the mechanisms underlying “pre-leukemic” cell dissemination are still unclear. Here we describe how deregulated Notch3 signaling enhances CXCR4 cell-surface expression and migratory ability of CD4(+)CD8(+) thymocyte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrandino, Francesca, Bernardini, Giovanni, Tsaouli, Georgia, Grazioli, Paola, Campese, Antonio Francesco, Noce, Claudia, Ciuffetta, Ambra, Vacca, Alessandra, Besharat, Zein Mersini, Bellavia, Diana, Screpanti, Isabella, Felli, Maria Pia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284016/ https://www.ncbi.nlm.nih.gov/pubmed/30038265 http://dx.doi.org/10.1038/s41388-018-0401-2

Ejemplares similares

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression
por: Tsaouli, Georgia, et al.
Publicado: (2019)

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer
por: Ferrandino, Francesca, et al.
Publicado: (2018)

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL()()
por: Pelullo, Maria, et al.
Publicado: (2014)

Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia
por: Grazioli, Paola, et al.
Publicado: (2022)

NF-κB1 Regulates Immune Environment and Outcome of Notch-Dependent T-Cell Acute Lymphoblastic Leukemia
por: Grazioli, Paola, et al.
Publicado: (2020)

Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line
por: Massimi, Isabella, et al.
Publicado: (2015)

Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)
por: Catanzaro, Giuseppina, et al.
Publicado: (2017)

Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
por: Giuli, Maria Valeria, et al.
Publicado: (2020)

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
por: Franciosa, G, et al.
Publicado: (2016)

NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest
por: Diluvio, Giulia, et al.
Publicado: (2018)

Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells
por: Radtke, Freddy, et al.
Publicado: (2000)

Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype
por: Giuli, M. V., et al.
Publicado: (2019)

The Intrathymic Pathogenesis of Myasthenia Gravis
por: Levinson, Arnold I., et al.
Publicado: (2004)

Primary intrathymic lymphangioma in an infant
por: Hiremath, Channabasavaraj S, et al.
Publicado: (2020)

Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells
por: Ceccarelli, Simona, et al.
Publicado: (2019)

Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer
por: Pelullo, Maria, et al.
Publicado: (2019)

Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy
por: Citarella, Anna, et al.
Publicado: (2023)

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
por: Tottone, Luca, et al.
Publicado: (2019)

A Dynamic Role of Mastermind-Like 1: A Journey Through the Main (Path)ways Between Development and Cancer
por: Zema, Sabrina, et al.
Publicado: (2020)

Neurotransmitters Modulate Intrathymic T-cell Development
por: Francelin, Carolina, et al.
Publicado: (2021)

Protocol for standardized intrathymic injection in mice
por: Tsai, Tsung-Lin, et al.
Publicado: (2023)

BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors
por: Miele, Evelina, et al.
Publicado: (2020)

Intrathymic differentiation of V gamma 3 T cells
Publicado: (1993)

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients
por: Catanzaro, Giuseppina, et al.
Publicado: (2018)

Low Expression of miR-466f-3p Sustains Epithelial to Mesenchymal Transition in Sonic Hedgehog Medulloblastoma Stem Cells Through Vegfa-Nrp2 Signaling Pathway
por: Besharat, Zein Mersini, et al.
Publicado: (2018)

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs
por: Catanzaro, Giuseppina, et al.
Publicado: (2016)

Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives
por: Zhdanovskaya, Nadezda, et al.
Publicado: (2021)

Nuclear factors that mediate intrathymic signals are developmentally regulated
Publicado: (1994)

Intrathymic Selection and Defects in the Thymic Epithelial Cell Development
por: García-Ceca, Javier, et al.
Publicado: (2020)

Intrathymic somatotropic circuitry: consequences upon thymus involution
por: Reis, Maria Danielma dos Santos, et al.
Publicado: (2023)

Environmental Contaminants Acting as Endocrine Disruptors Modulate Atherogenic Processes: New Risk Factors for Cardiovascular Diseases in Women?
por: Migliaccio, Silvia, et al.
Publicado: (2021)

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells
Publicado: (1985)

Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease
por: Yamamoto, Yohei, et al.
Publicado: (2021)

Technique for ectopic intrathymic parathyroid adenoma: the uniportal subxiphoid approach
por: Hartert, Marc, et al.
Publicado: (2021)

ODP075 A Rare Case of Intrathymic Parathyroid Adenoma
por: Heluey, Camila, et al.
Publicado: (2022)

Application of Small Epigenetic Modulators in Pediatric Medulloblastoma
por: Zwergel, Clemens, et al.
Publicado: (2018)

β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest
por: Po, Agnese, et al.
Publicado: (2017)

Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells
por: Po, Agnese, et al.
Publicado: (2020)

PLK1 targets NOTCH1 during DNA damage and mitotic progression
por: De Blasio, Carlo, et al.
Publicado: (2019)

NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells
por: Di Ianni, Mauro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qq3e7ce3v3qesicmb9v29nc9uc