Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial. After different conditioning paradigms and bone marrow (BM) or hematopoietic stem cell (HSC) transplantation, graft-derived cells seed the brain and persi...

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Detalles Bibliográficos
Autores principales: Shemer, Anat, Grozovski, Jonathan, Tay, Tuan Leng, Tao, Jenhan, Volaski, Alon, Süß, Patrick, Ardura-Fabregat, Alberto, Gross-Vered, Mor, Kim, Jung-Seok, David, Eyal, Chappell-Maor, Louise, Thielecke, Lars, Glass, Christopher K., Cornils, Kerstin, Prinz, Marco, Jung, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284018/
https://www.ncbi.nlm.nih.gov/pubmed/30523248
http://dx.doi.org/10.1038/s41467-018-07548-5

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