Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the hippocampus, sometimes spread to the insulo-perisylvian regions and may progress to secondary generalized seizures. Mor...

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Detalles Bibliográficos
Autores principales: Cavarsan, Clarissa F., Malheiros, Jackeline, Hamani, Clement, Najm, Imad, Covolan, Luciene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284045/
https://www.ncbi.nlm.nih.gov/pubmed/30555406
http://dx.doi.org/10.3389/fneur.2018.01023
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author Cavarsan, Clarissa F.
Malheiros, Jackeline
Hamani, Clement
Najm, Imad
Covolan, Luciene
author_facet Cavarsan, Clarissa F.
Malheiros, Jackeline
Hamani, Clement
Najm, Imad
Covolan, Luciene
author_sort Cavarsan, Clarissa F.
collection PubMed
description Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the hippocampus, sometimes spread to the insulo-perisylvian regions and may progress to secondary generalized seizures. Morphological alterations in hippocampal sclerosis are well defined. Among them, hippocampal sclerosis is characterized by prominent cell loss in the hilus and CA1, and abnormal mossy fiber sprouting (granular cell axons) into the dentate gyrus inner molecular layer. In this review, we highlight the role of mossy fiber sprouting in seizure generation and hippocampal excitability and discuss the response of alternative treatment strategies in terms of MFS and spontaneous recurrent seizures in models of TLE (temporal lobe epilepsy).
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spelling pubmed-62840452018-12-14 Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy? Cavarsan, Clarissa F. Malheiros, Jackeline Hamani, Clement Najm, Imad Covolan, Luciene Front Neurol Neurology Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the hippocampus, sometimes spread to the insulo-perisylvian regions and may progress to secondary generalized seizures. Morphological alterations in hippocampal sclerosis are well defined. Among them, hippocampal sclerosis is characterized by prominent cell loss in the hilus and CA1, and abnormal mossy fiber sprouting (granular cell axons) into the dentate gyrus inner molecular layer. In this review, we highlight the role of mossy fiber sprouting in seizure generation and hippocampal excitability and discuss the response of alternative treatment strategies in terms of MFS and spontaneous recurrent seizures in models of TLE (temporal lobe epilepsy). Frontiers Media S.A. 2018-11-30 /pmc/articles/PMC6284045/ /pubmed/30555406 http://dx.doi.org/10.3389/fneur.2018.01023 Text en Copyright © 2018 Cavarsan, Malheiros, Hamani, Najm and Covolan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Cavarsan, Clarissa F.
Malheiros, Jackeline
Hamani, Clement
Najm, Imad
Covolan, Luciene
Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?
title Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?
title_full Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?
title_fullStr Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?
title_full_unstemmed Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?
title_short Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?
title_sort is mossy fiber sprouting a potential therapeutic target for epilepsy?
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284045/
https://www.ncbi.nlm.nih.gov/pubmed/30555406
http://dx.doi.org/10.3389/fneur.2018.01023
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