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Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site

Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant mutations at the hormone binding pocket (HBP) that convert the activity of these agents from antagonist to agonist. Thus, there is a high unmet me...

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Detalles Bibliográficos
Autores principales:	Liu, Yangguang, Wu, Meng, Wang, Tianqi, Xie, Yongli, Cui, Xiangling, He, Liujun, He, Yang, Li, Xiaoyu, Liu, Mingliang, Hu, Laixing, Cen, Shan, Zhou, Jinming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284051/ https://www.ncbi.nlm.nih.gov/pubmed/30555332 http://dx.doi.org/10.3389/fphar.2018.01419

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