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Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice
Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine formula, is used as a remedy for conditions, and physical weakness. Cancer cachexia is seen in advanced cancer patients and is defined by an ongoing loss of skeletal-muscle mass that leads to progressive functional impairment. In the present...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284053/ https://www.ncbi.nlm.nih.gov/pubmed/30555329 http://dx.doi.org/10.3389/fphar.2018.01400 |
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author | Ohsawa, Masahiro Maruoka, Junya Inami, Chihiro Iwaki, Anna Murakami, Tomoyasu Ishikura, Kei-ichiro |
author_facet | Ohsawa, Masahiro Maruoka, Junya Inami, Chihiro Iwaki, Anna Murakami, Tomoyasu Ishikura, Kei-ichiro |
author_sort | Ohsawa, Masahiro |
collection | PubMed |
description | Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine formula, is used as a remedy for conditions, and physical weakness. Cancer cachexia is seen in advanced cancer patients and is defined by an ongoing loss of skeletal-muscle mass that leads to progressive functional impairment. In the present study, we examined the hypothesis whether NYT improves the functional loss of skeletal muscle cancer cachexia. Male C57/BL 6J mice with B16BF6 melanoma tumor showed decreased expression of myosin heavy chain (MHC) in the gastrocnemius muscle. Moreover, the expression of SOCS3 and phosphorylated STAT3 and AMPK was increased, and the expression of phosphorylated 4E-BP1 was decreased in the gastrocnemius muscle of tumor-bearing mice. These data suggested that amino acid metabolism was altered in tumor-bearing mice, which were normalized by the NYT intervention. The present study showed that NYT might be a novel therapeutic option for the treatment of sarcopenia occurring cancer cachexia. |
format | Online Article Text |
id | pubmed-6284053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62840532018-12-14 Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice Ohsawa, Masahiro Maruoka, Junya Inami, Chihiro Iwaki, Anna Murakami, Tomoyasu Ishikura, Kei-ichiro Front Pharmacol Pharmacology Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine formula, is used as a remedy for conditions, and physical weakness. Cancer cachexia is seen in advanced cancer patients and is defined by an ongoing loss of skeletal-muscle mass that leads to progressive functional impairment. In the present study, we examined the hypothesis whether NYT improves the functional loss of skeletal muscle cancer cachexia. Male C57/BL 6J mice with B16BF6 melanoma tumor showed decreased expression of myosin heavy chain (MHC) in the gastrocnemius muscle. Moreover, the expression of SOCS3 and phosphorylated STAT3 and AMPK was increased, and the expression of phosphorylated 4E-BP1 was decreased in the gastrocnemius muscle of tumor-bearing mice. These data suggested that amino acid metabolism was altered in tumor-bearing mice, which were normalized by the NYT intervention. The present study showed that NYT might be a novel therapeutic option for the treatment of sarcopenia occurring cancer cachexia. Frontiers Media S.A. 2018-11-30 /pmc/articles/PMC6284053/ /pubmed/30555329 http://dx.doi.org/10.3389/fphar.2018.01400 Text en Copyright © 2018 Ohsawa, Maruoka, Inami, Iwaki, Murakami and Ishikura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ohsawa, Masahiro Maruoka, Junya Inami, Chihiro Iwaki, Anna Murakami, Tomoyasu Ishikura, Kei-ichiro Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice |
title | Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice |
title_full | Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice |
title_fullStr | Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice |
title_full_unstemmed | Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice |
title_short | Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice |
title_sort | effect of ninjin’yoeito on the loss of skeletal muscle function in cancer-bearing mice |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284053/ https://www.ncbi.nlm.nih.gov/pubmed/30555329 http://dx.doi.org/10.3389/fphar.2018.01400 |
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