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Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome

Caspase-11 is a cytosolic sensor and protease that drives innate immune responses to the bacterial cell wall component, LPS. Caspase-11 provides defence against cytosolic Gram-negative bacteria; however, excessive caspase-11 responses contribute to murine endotoxic shock. Upon sensing LPS, caspase-1...

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Detalles Bibliográficos
Autores principales:	Ross, Connie, Chan, Amy H, Von Pein, Jessica, Boucher, Dave, Schroder, Kate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284101/ https://www.ncbi.nlm.nih.gov/pubmed/30564782 http://dx.doi.org/10.26508/lsa.201800237

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