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Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias

Cardiac arrhythmias, commonly diagnosed in young people, involve multiple etiopathogenic factors, including oxidative stress. Purpose: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals in...

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Autores principales: BEZNĂ, M.C., CÂRSTEA, D., BEZNĂ, M., PISOSCHI, C., ISTRĂTOAIE, O., ALEXANDRU, D.O., EFREM, C., MELINTE, R.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284178/
https://www.ncbi.nlm.nih.gov/pubmed/30595866
http://dx.doi.org/10.12865/CHSJ.43.02.03
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author BEZNĂ, M.C.
CÂRSTEA, D.
BEZNĂ, M.
PISOSCHI, C.
ISTRĂTOAIE, O.
ALEXANDRU, D.O.
EFREM, C.
MELINTE, R.P.
author_facet BEZNĂ, M.C.
CÂRSTEA, D.
BEZNĂ, M.
PISOSCHI, C.
ISTRĂTOAIE, O.
ALEXANDRU, D.O.
EFREM, C.
MELINTE, R.P.
author_sort BEZNĂ, M.C.
collection PubMed
description Cardiac arrhythmias, commonly diagnosed in young people, involve multiple etiopathogenic factors, including oxidative stress. Purpose: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals into oxygen and water) in young patients with cardiac arrhythmias. Material and method: The study was conducted on a group of 40 young patients with a mean age of 34 years old, of both sexes, with non-lesional cardiac dysrhythmias, compared to a control group of 40 healthy subjects, determining for both groups the SOD serum level. Diagnosis of cardiac rhythm disorder was supported by electrocardiogram, imaging and laboratory investigations. Results: SOD recorded a 61% decrease of mean values in patients compared to controls. The decreasing variation was found in all arrhythmia types, as follows: atrial fibrillation (51,54%), sinus bradycardia (54,86%), atrial flutter (55,71%), extrasystolic ventricular arrhythmia (64,20%), extrasystolic atrial arrhythmia (65,27%), combined arrhythmias (65,93%), supraventricular paroxysmal tachycardia (71,32%) and sinus tachycardia (74,24%). SOD deficiency demonstrates the involvement of oxidative stress in cardiac arrhythmic pathogenesis, excess oxygen radicals interfering with multiple mechanisms related to the onset of arrhythmogenesis. The SOD decrease was more important in females (60,57%) than in males (67,06%) and in those with nutrition poor in antioxidants. Conclusions: SOD estimation represents a biomarker whose decrease and deficiency implies occurrence of oxidative stress and implicitly highlights its role in cardiac arrhythmic pathology in young people, with the possibility of monitoring and correction by pharmacological or non-pharmacological therapeutic means.
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spelling pubmed-62841782018-12-28 Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias BEZNĂ, M.C. CÂRSTEA, D. BEZNĂ, M. PISOSCHI, C. ISTRĂTOAIE, O. ALEXANDRU, D.O. EFREM, C. MELINTE, R.P. Curr Health Sci J Original Paper Cardiac arrhythmias, commonly diagnosed in young people, involve multiple etiopathogenic factors, including oxidative stress. Purpose: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals into oxygen and water) in young patients with cardiac arrhythmias. Material and method: The study was conducted on a group of 40 young patients with a mean age of 34 years old, of both sexes, with non-lesional cardiac dysrhythmias, compared to a control group of 40 healthy subjects, determining for both groups the SOD serum level. Diagnosis of cardiac rhythm disorder was supported by electrocardiogram, imaging and laboratory investigations. Results: SOD recorded a 61% decrease of mean values in patients compared to controls. The decreasing variation was found in all arrhythmia types, as follows: atrial fibrillation (51,54%), sinus bradycardia (54,86%), atrial flutter (55,71%), extrasystolic ventricular arrhythmia (64,20%), extrasystolic atrial arrhythmia (65,27%), combined arrhythmias (65,93%), supraventricular paroxysmal tachycardia (71,32%) and sinus tachycardia (74,24%). SOD deficiency demonstrates the involvement of oxidative stress in cardiac arrhythmic pathogenesis, excess oxygen radicals interfering with multiple mechanisms related to the onset of arrhythmogenesis. The SOD decrease was more important in females (60,57%) than in males (67,06%) and in those with nutrition poor in antioxidants. Conclusions: SOD estimation represents a biomarker whose decrease and deficiency implies occurrence of oxidative stress and implicitly highlights its role in cardiac arrhythmic pathology in young people, with the possibility of monitoring and correction by pharmacological or non-pharmacological therapeutic means. Medical University Publishing House Craiova 2017 2017-06-29 /pmc/articles/PMC6284178/ /pubmed/30595866 http://dx.doi.org/10.12865/CHSJ.43.02.03 Text en Copyright © 2017, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
BEZNĂ, M.C.
CÂRSTEA, D.
BEZNĂ, M.
PISOSCHI, C.
ISTRĂTOAIE, O.
ALEXANDRU, D.O.
EFREM, C.
MELINTE, R.P.
Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias
title Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias
title_full Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias
title_fullStr Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias
title_full_unstemmed Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias
title_short Estimation of Oxidative Stress Involvement by Superoxide Dismutase Variation in Cardiac Arrhythmias
title_sort estimation of oxidative stress involvement by superoxide dismutase variation in cardiac arrhythmias
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284178/
https://www.ncbi.nlm.nih.gov/pubmed/30595866
http://dx.doi.org/10.12865/CHSJ.43.02.03
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