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Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds

BACKGROUND: In practice, field evaluation of vaccine efficacy in individual herds is often based on a historical comparison of productivity data following initiation of vaccination. Being biased by time, this study design highly contrasts the more controlled, parallel-group design used for most init...

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Autores principales: Nielsen, Gitte Blach, Haugegaard, John, Jolie, Rika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284288/
https://www.ncbi.nlm.nih.gov/pubmed/30546913
http://dx.doi.org/10.1186/s40813-018-0104-7
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author Nielsen, Gitte Blach
Haugegaard, John
Jolie, Rika
author_facet Nielsen, Gitte Blach
Haugegaard, John
Jolie, Rika
author_sort Nielsen, Gitte Blach
collection PubMed
description BACKGROUND: In practice, field evaluation of vaccine efficacy in individual herds is often based on a historical comparison of productivity data following initiation of vaccination. Being biased by time, this study design highly contrasts the more controlled, parallel-group design used for most initial vaccine efficacy studies but offers the possibility of including a larger number of animals and herds. As an important add-on to previous findings in controlled studies, the objective of this study was to evaluate the field efficacy of the ready-to-use combination vaccine Porcilis® PCV M Hyo (MSD Animal Health) by an observational historical study design using routinely generated herd productivity data. RESULTS: Data on mortality, average daily weight gain and feed conversion rate were collected as yearly averages for one year prior to and one year after implementation of Porcilis® PCV M Hyo vaccination from 20 nursery and 23 finishing herds. When comparing pre- and post-vaccination periods, the average improvements in productivity data amounted to − 0.4 percentage points for mortality (p = 0.014), + 5 g for average daily weight gain (p = 0.555) and − 0.06 feeding units(FU)/kg for feed conversion rate (p = 0.074) in nursery herds and − 0.5 percentage points for mortality (p = 0.012), + 34 g for average daily weight gain (p < 0.001) and − 0.04 FU/kg for feed conversion rate (p = 0.133) in finishing herds. Even though some nursery and finishing herds also previously vaccinated against PCV2 and/or Mycoplasma hyopneumoniae, this did not significantly affect the results. For finishers, these results were obtained when difference in arrival weights between the periods and shared ownership of the herds were additionally taken into account. CONCLUSION: In these 20 nursery and 23 finishing herds, previous findings from parallel-group vaccination studies concerning average daily weight gain for finishers were confirmed. Additionally, a significant effect on mortality for both nursery and finishing herds was demonstrated in this evaluation based on routinely generated herd productivity data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40813-018-0104-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-62842882018-12-13 Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds Nielsen, Gitte Blach Haugegaard, John Jolie, Rika Porcine Health Manag Short Communication BACKGROUND: In practice, field evaluation of vaccine efficacy in individual herds is often based on a historical comparison of productivity data following initiation of vaccination. Being biased by time, this study design highly contrasts the more controlled, parallel-group design used for most initial vaccine efficacy studies but offers the possibility of including a larger number of animals and herds. As an important add-on to previous findings in controlled studies, the objective of this study was to evaluate the field efficacy of the ready-to-use combination vaccine Porcilis® PCV M Hyo (MSD Animal Health) by an observational historical study design using routinely generated herd productivity data. RESULTS: Data on mortality, average daily weight gain and feed conversion rate were collected as yearly averages for one year prior to and one year after implementation of Porcilis® PCV M Hyo vaccination from 20 nursery and 23 finishing herds. When comparing pre- and post-vaccination periods, the average improvements in productivity data amounted to − 0.4 percentage points for mortality (p = 0.014), + 5 g for average daily weight gain (p = 0.555) and − 0.06 feeding units(FU)/kg for feed conversion rate (p = 0.074) in nursery herds and − 0.5 percentage points for mortality (p = 0.012), + 34 g for average daily weight gain (p < 0.001) and − 0.04 FU/kg for feed conversion rate (p = 0.133) in finishing herds. Even though some nursery and finishing herds also previously vaccinated against PCV2 and/or Mycoplasma hyopneumoniae, this did not significantly affect the results. For finishers, these results were obtained when difference in arrival weights between the periods and shared ownership of the herds were additionally taken into account. CONCLUSION: In these 20 nursery and 23 finishing herds, previous findings from parallel-group vaccination studies concerning average daily weight gain for finishers were confirmed. Additionally, a significant effect on mortality for both nursery and finishing herds was demonstrated in this evaluation based on routinely generated herd productivity data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40813-018-0104-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-07 /pmc/articles/PMC6284288/ /pubmed/30546913 http://dx.doi.org/10.1186/s40813-018-0104-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Communication
Nielsen, Gitte Blach
Haugegaard, John
Jolie, Rika
Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
title Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
title_full Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
title_fullStr Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
title_full_unstemmed Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
title_short Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
title_sort field evaluation of a ready-to-use combined porcine circovirus type 2 and mycoplasma hyopneumoniae vaccine in denmark – a historical comparison of productivity parameters in 20 nursery and 23 finishing herds
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284288/
https://www.ncbi.nlm.nih.gov/pubmed/30546913
http://dx.doi.org/10.1186/s40813-018-0104-7
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