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Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study

BACKGROUND: Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC). METHODS: Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched fo...

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Autores principales: Hao, Bo, Yu, Miaomei, Sang, Chen, Bi, Baochen, Chen, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284307/
https://www.ncbi.nlm.nih.gov/pubmed/30522496
http://dx.doi.org/10.1186/s12944-018-0925-z
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author Hao, Bo
Yu, Miaomei
Sang, Chen
Bi, Baochen
Chen, Jiajun
author_facet Hao, Bo
Yu, Miaomei
Sang, Chen
Bi, Baochen
Chen, Jiajun
author_sort Hao, Bo
collection PubMed
description BACKGROUND: Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC). METHODS: Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC. Demographic and clinical data were obtained from patients’ medical records and telephone interviews. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. RESULTS: Abnormal triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels showed statistically significant coexistence with NSCLC compared with controls. Higher levels of TG were associated with a higher risk of NSCLC (OR = 1.541, 95% CI, (1.072–2.215)). The odds ratios (ORs) for NSCLC for normal and high levels of HDL-C versus those with a low level of HDL-C were 0.337(95% CI, (0.242–0.468)) and 0.288(95% CI, (0.185–0.448)), respectively. After adjustment for age, sex, smoking status, hypertension, body mass index, diabetes and lipid profiles, the adjusted OR for normal and high levels of HDL-C were 0.320(95% CI, (0.218–0.470)) and 0.233(95% CI, (0.134–0.407)), respectively. However, after adjustment, high levels of TG increased the risk of NSCLC but not significantly (OR = 1.052, 95% CI (0.671–1.649)). CONCLUSIONS: This study provided evidence that dyslipidemia increased the risk of NSCLC in Chinese population.
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spelling pubmed-62843072018-12-14 Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study Hao, Bo Yu, Miaomei Sang, Chen Bi, Baochen Chen, Jiajun Lipids Health Dis Research BACKGROUND: Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC). METHODS: Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC. Demographic and clinical data were obtained from patients’ medical records and telephone interviews. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. RESULTS: Abnormal triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels showed statistically significant coexistence with NSCLC compared with controls. Higher levels of TG were associated with a higher risk of NSCLC (OR = 1.541, 95% CI, (1.072–2.215)). The odds ratios (ORs) for NSCLC for normal and high levels of HDL-C versus those with a low level of HDL-C were 0.337(95% CI, (0.242–0.468)) and 0.288(95% CI, (0.185–0.448)), respectively. After adjustment for age, sex, smoking status, hypertension, body mass index, diabetes and lipid profiles, the adjusted OR for normal and high levels of HDL-C were 0.320(95% CI, (0.218–0.470)) and 0.233(95% CI, (0.134–0.407)), respectively. However, after adjustment, high levels of TG increased the risk of NSCLC but not significantly (OR = 1.052, 95% CI (0.671–1.649)). CONCLUSIONS: This study provided evidence that dyslipidemia increased the risk of NSCLC in Chinese population. BioMed Central 2018-12-06 /pmc/articles/PMC6284307/ /pubmed/30522496 http://dx.doi.org/10.1186/s12944-018-0925-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Hao, Bo
Yu, Miaomei
Sang, Chen
Bi, Baochen
Chen, Jiajun
Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
title Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
title_full Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
title_fullStr Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
title_full_unstemmed Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
title_short Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study
title_sort dyslipidemia and non-small cell lung cancer risk in chinese population: a case-control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284307/
https://www.ncbi.nlm.nih.gov/pubmed/30522496
http://dx.doi.org/10.1186/s12944-018-0925-z
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