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Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days
BACKGROUND: To develop human space exploration, it is necessary to study the effects of an isolated and confined environment, as well as a microgravity environment, on cerebral circulation. However, no studies on cerebral circulation in an isolated and confined environment have been reported. Theref...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284313/ https://www.ncbi.nlm.nih.gov/pubmed/30522430 http://dx.doi.org/10.1186/s12199-018-0751-y |
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author | Kato, Tomokazu Yanagida, Ryo Takko, Chiharu Kurazumi, Takuya Inoue, Natsuhiko Suzuki, Go Ogawa, Yojiro Furukawa, Satoshi Iwasaki, Ken-ichi |
author_facet | Kato, Tomokazu Yanagida, Ryo Takko, Chiharu Kurazumi, Takuya Inoue, Natsuhiko Suzuki, Go Ogawa, Yojiro Furukawa, Satoshi Iwasaki, Ken-ichi |
author_sort | Kato, Tomokazu |
collection | PubMed |
description | BACKGROUND: To develop human space exploration, it is necessary to study the effects of an isolated and confined environment, as well as a microgravity environment, on cerebral circulation. However, no studies on cerebral circulation in an isolated and confined environment have been reported. Therefore, we investigated the effects of a 14-day period of confinement in an isolated environment on dynamic cerebral autoregulation. METHODS: We participated in an isolation and confinement experiment conducted by the Japan Aerospace Exploration Agency in 2016. Eight healthy males were isolated and confined in a facility for 14 days. Data were collected on the days immediately before and after confinement. Arterial blood pressure waveforms were obtained using a finger blood pressure monitor, and cerebral blood flow velocity waveforms in the middle cerebral artery were obtained using transcranial Doppler ultrasonography for 6 min during quiet rest in a supine position. Dynamic cerebral autoregulation was evaluated by transfer function analysis between spontaneous variability of beat-to-beat mean arterial blood pressure and mean cerebral blood flow velocity. RESULTS: Transfer function gain in the low- and high-frequency ranges increased significantly (0.54 ± 0.07 to 0.69 ± 0.09 cm/s/mmHg and 0.80 ± 0.05 to 0.92 ± 0.09 cm/s/mmHg, respectively) after the confinement. CONCLUSION: The increases observed in transfer function gain may be interpreted as indicating less suppressive capability against transmission from arterial blood pressure oscillation to cerebral blood flow velocity fluctuation. These results suggest that confinement in an isolated environment for 14 days may impair dynamic cerebral autoregulation. TRIAL REGISTRATION: UMIN000020703, Registered 2016/01/22. |
format | Online Article Text |
id | pubmed-6284313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62843132018-12-13 Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days Kato, Tomokazu Yanagida, Ryo Takko, Chiharu Kurazumi, Takuya Inoue, Natsuhiko Suzuki, Go Ogawa, Yojiro Furukawa, Satoshi Iwasaki, Ken-ichi Environ Health Prev Med Research Article BACKGROUND: To develop human space exploration, it is necessary to study the effects of an isolated and confined environment, as well as a microgravity environment, on cerebral circulation. However, no studies on cerebral circulation in an isolated and confined environment have been reported. Therefore, we investigated the effects of a 14-day period of confinement in an isolated environment on dynamic cerebral autoregulation. METHODS: We participated in an isolation and confinement experiment conducted by the Japan Aerospace Exploration Agency in 2016. Eight healthy males were isolated and confined in a facility for 14 days. Data were collected on the days immediately before and after confinement. Arterial blood pressure waveforms were obtained using a finger blood pressure monitor, and cerebral blood flow velocity waveforms in the middle cerebral artery were obtained using transcranial Doppler ultrasonography for 6 min during quiet rest in a supine position. Dynamic cerebral autoregulation was evaluated by transfer function analysis between spontaneous variability of beat-to-beat mean arterial blood pressure and mean cerebral blood flow velocity. RESULTS: Transfer function gain in the low- and high-frequency ranges increased significantly (0.54 ± 0.07 to 0.69 ± 0.09 cm/s/mmHg and 0.80 ± 0.05 to 0.92 ± 0.09 cm/s/mmHg, respectively) after the confinement. CONCLUSION: The increases observed in transfer function gain may be interpreted as indicating less suppressive capability against transmission from arterial blood pressure oscillation to cerebral blood flow velocity fluctuation. These results suggest that confinement in an isolated environment for 14 days may impair dynamic cerebral autoregulation. TRIAL REGISTRATION: UMIN000020703, Registered 2016/01/22. BioMed Central 2018-12-06 2018 /pmc/articles/PMC6284313/ /pubmed/30522430 http://dx.doi.org/10.1186/s12199-018-0751-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kato, Tomokazu Yanagida, Ryo Takko, Chiharu Kurazumi, Takuya Inoue, Natsuhiko Suzuki, Go Ogawa, Yojiro Furukawa, Satoshi Iwasaki, Ken-ichi Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
title | Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
title_full | Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
title_fullStr | Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
title_full_unstemmed | Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
title_short | Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
title_sort | dynamic cerebral autoregulation after confinement in an isolated environment for 14 days |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284313/ https://www.ncbi.nlm.nih.gov/pubmed/30522430 http://dx.doi.org/10.1186/s12199-018-0751-y |
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