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Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study
Background: Bacillus Calmette-Guérin (BCG) vaccination may have beneficial non-specific effects on child survival, the effects being stronger for children developing a scar. In a prospective cohort study, we examined determinants for not developing a BCG scar within 6 months of vaccination. Methods:...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284494/ https://www.ncbi.nlm.nih.gov/pubmed/29293396 http://dx.doi.org/10.1080/21645515.2017.1421879 |
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author | Funch, Katarina M. Thysen, Sanne M. Rodrigues, Amabelia Martins, Cesario L. Aaby, Peter Benn, Christine S. Fisker, Ane B. |
author_facet | Funch, Katarina M. Thysen, Sanne M. Rodrigues, Amabelia Martins, Cesario L. Aaby, Peter Benn, Christine S. Fisker, Ane B. |
author_sort | Funch, Katarina M. |
collection | PubMed |
description | Background: Bacillus Calmette-Guérin (BCG) vaccination may have beneficial non-specific effects on child survival, the effects being stronger for children developing a scar. In a prospective cohort study, we examined determinants for not developing a BCG scar within 6 months of vaccination. Methods: Bandim Health Project (BHP) runs a Health and Demographic Surveillance System site in rural Guinea-Bissau. BHP provides BCG at monthly visits. We studied determinants for not developing a BCG scar using binomial regression models to obtain relative risks (RR). Results: From May 2012 until October 2014, BHP nurses vaccinated 2415 infants with BCG. We assessed BCG scar between 6 and 12 months of age for 2156 (89%) of these children and 2115 (98%) had developed a scar. In comparison, among 785 children BCG vaccinated elsewhere, 622 (79%) had a scar, the RR of not having a scar being 10.91 (7.52-15.85) compared with children vaccinated by BHP. Among children vaccinated by BHP, those receiving the Russian BCG strain were more likely not to develop a scar (RR = 2.98 (1.52–5.81)) compared with children receiving Danish BCG strain. Children with no post-injection wheal or a wheal <3 mm were more likely to not develop a scar (RR = 9.05 (3.69–22.20) and RR = 4.74 (1.96–11.45), respectively). Nutritional status and socioeconomic status were not associated with scarification. Conclusion: Vaccination technique and vaccine strain were associated with BCG scar development while nutritional status and socioeconomic status were not. Scarring rate may therefore be a better indicator of vaccination programme performance than coverage. |
format | Online Article Text |
id | pubmed-6284494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-62844942018-12-10 Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study Funch, Katarina M. Thysen, Sanne M. Rodrigues, Amabelia Martins, Cesario L. Aaby, Peter Benn, Christine S. Fisker, Ane B. Hum Vaccin Immunother Research Paper Background: Bacillus Calmette-Guérin (BCG) vaccination may have beneficial non-specific effects on child survival, the effects being stronger for children developing a scar. In a prospective cohort study, we examined determinants for not developing a BCG scar within 6 months of vaccination. Methods: Bandim Health Project (BHP) runs a Health and Demographic Surveillance System site in rural Guinea-Bissau. BHP provides BCG at monthly visits. We studied determinants for not developing a BCG scar using binomial regression models to obtain relative risks (RR). Results: From May 2012 until October 2014, BHP nurses vaccinated 2415 infants with BCG. We assessed BCG scar between 6 and 12 months of age for 2156 (89%) of these children and 2115 (98%) had developed a scar. In comparison, among 785 children BCG vaccinated elsewhere, 622 (79%) had a scar, the RR of not having a scar being 10.91 (7.52-15.85) compared with children vaccinated by BHP. Among children vaccinated by BHP, those receiving the Russian BCG strain were more likely not to develop a scar (RR = 2.98 (1.52–5.81)) compared with children receiving Danish BCG strain. Children with no post-injection wheal or a wheal <3 mm were more likely to not develop a scar (RR = 9.05 (3.69–22.20) and RR = 4.74 (1.96–11.45), respectively). Nutritional status and socioeconomic status were not associated with scarification. Conclusion: Vaccination technique and vaccine strain were associated with BCG scar development while nutritional status and socioeconomic status were not. Scarring rate may therefore be a better indicator of vaccination programme performance than coverage. Taylor & Francis 2018-01-23 /pmc/articles/PMC6284494/ /pubmed/29293396 http://dx.doi.org/10.1080/21645515.2017.1421879 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Research Paper Funch, Katarina M. Thysen, Sanne M. Rodrigues, Amabelia Martins, Cesario L. Aaby, Peter Benn, Christine S. Fisker, Ane B. Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study |
title | Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study |
title_full | Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study |
title_fullStr | Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study |
title_full_unstemmed | Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study |
title_short | Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study |
title_sort | determinants of bcg scarification among children in rural guinea-bissau: a prospective cohort study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284494/ https://www.ncbi.nlm.nih.gov/pubmed/29293396 http://dx.doi.org/10.1080/21645515.2017.1421879 |
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