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Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells
BACKGROUND: Peritoneal metastasis frequently occurs in patients with advanced ovarian cancer and is the main basis for a poor prognosis. The mechanism underlying preferential ovarian cancer spread to the peritoneum is not well understood. METHODS: Herein, we investigated the significance and mechani...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284525/ https://www.ncbi.nlm.nih.gov/pubmed/30584359 http://dx.doi.org/10.2147/CMAR.S183043 |
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author | Wang, Jinou Liu, Chang Chang, Xiaoying Qi, Yafei Zhu, Zhi Yang, Xianghong |
author_facet | Wang, Jinou Liu, Chang Chang, Xiaoying Qi, Yafei Zhu, Zhi Yang, Xianghong |
author_sort | Wang, Jinou |
collection | PubMed |
description | BACKGROUND: Peritoneal metastasis frequently occurs in patients with advanced ovarian cancer and is the main basis for a poor prognosis. The mechanism underlying preferential ovarian cancer spread to the peritoneum is not well understood. METHODS: Herein, we investigated the significance and mechanism underlying fibrosis of mesothelial cells promoting peritoneal implantation of ovarian cancer. We have assessed the mesothelial cell fibroblast transformation process in peritoneal tissues of omentum and fibrotic mesothelial cell release of chemokines to promote dissemination by scanning electron microscopy, ELISA, Western blot, and Transwell chamber assay. RESULTS: We showed that the fibrosis of mesothelial cells exists in the peritoneum of ovarian cancer patients with peritoneal metastasis. Fibrosis of the mesothelial cells was induced by TGF-β1, which upregulates the CXCL12–CXCR4 and CXCL16–CXCR6 axes of mesothelial cells. CONCLUSION: CXCL12–CXCR4 and CXCL16–CXCR6 may be important signaling pathways closely involved in peritoneal metastasis of ovarian cancer that require further investigation. The findings may lead to developing alternative strategies aimed at preventing and treating the metastasis of ovarian cancer. |
format | Online Article Text |
id | pubmed-6284525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62845252018-12-24 Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells Wang, Jinou Liu, Chang Chang, Xiaoying Qi, Yafei Zhu, Zhi Yang, Xianghong Cancer Manag Res Original Research BACKGROUND: Peritoneal metastasis frequently occurs in patients with advanced ovarian cancer and is the main basis for a poor prognosis. The mechanism underlying preferential ovarian cancer spread to the peritoneum is not well understood. METHODS: Herein, we investigated the significance and mechanism underlying fibrosis of mesothelial cells promoting peritoneal implantation of ovarian cancer. We have assessed the mesothelial cell fibroblast transformation process in peritoneal tissues of omentum and fibrotic mesothelial cell release of chemokines to promote dissemination by scanning electron microscopy, ELISA, Western blot, and Transwell chamber assay. RESULTS: We showed that the fibrosis of mesothelial cells exists in the peritoneum of ovarian cancer patients with peritoneal metastasis. Fibrosis of the mesothelial cells was induced by TGF-β1, which upregulates the CXCL12–CXCR4 and CXCL16–CXCR6 axes of mesothelial cells. CONCLUSION: CXCL12–CXCR4 and CXCL16–CXCR6 may be important signaling pathways closely involved in peritoneal metastasis of ovarian cancer that require further investigation. The findings may lead to developing alternative strategies aimed at preventing and treating the metastasis of ovarian cancer. Dove Medical Press 2018-12-04 /pmc/articles/PMC6284525/ /pubmed/30584359 http://dx.doi.org/10.2147/CMAR.S183043 Text en © 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Wang, Jinou Liu, Chang Chang, Xiaoying Qi, Yafei Zhu, Zhi Yang, Xianghong Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
title | Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
title_full | Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
title_fullStr | Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
title_full_unstemmed | Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
title_short | Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
title_sort | fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284525/ https://www.ncbi.nlm.nih.gov/pubmed/30584359 http://dx.doi.org/10.2147/CMAR.S183043 |
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