The role of microfluidics in protein formulations with pre-programmed functional characteristics

Protein-based therapies hold great promise for treating many diseases. Nevertheless, the challenges of producing therapies with targeted attributes via standardized processes may hinder the development of protein formulations and clinical translation of the advanced therapies. Microfluidics represen...

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Detalles Bibliográficos
Autores principales: Meng, Hu, Deng, Shuai, You, Yajing, Chan, Hon Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284529/
https://www.ncbi.nlm.nih.gov/pubmed/30584273
http://dx.doi.org/10.2147/BTT.S126725
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author Meng, Hu
Deng, Shuai
You, Yajing
Chan, Hon Fai
author_facet Meng, Hu
Deng, Shuai
You, Yajing
Chan, Hon Fai
author_sort Meng, Hu
collection PubMed
description Protein-based therapies hold great promise for treating many diseases. Nevertheless, the challenges of producing therapies with targeted attributes via standardized processes may hinder the development of protein formulations and clinical translation of the advanced therapies. Microfluidics represents a promising technology to develop protein formulations with pre-programmed functional characteristics, including size, morphology, and controlled drug release property. In this review, we discuss some examples of adopting microfluidics for fabricating particle- and fiber/tube-based formulations and highlight the advantages of microfluidics-assisted fabrication.
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spelling pubmed-62845292018-12-24 The role of microfluidics in protein formulations with pre-programmed functional characteristics Meng, Hu Deng, Shuai You, Yajing Chan, Hon Fai Biologics Review Protein-based therapies hold great promise for treating many diseases. Nevertheless, the challenges of producing therapies with targeted attributes via standardized processes may hinder the development of protein formulations and clinical translation of the advanced therapies. Microfluidics represents a promising technology to develop protein formulations with pre-programmed functional characteristics, including size, morphology, and controlled drug release property. In this review, we discuss some examples of adopting microfluidics for fabricating particle- and fiber/tube-based formulations and highlight the advantages of microfluidics-assisted fabrication. Dove Medical Press 2018-12-03 /pmc/articles/PMC6284529/ /pubmed/30584273 http://dx.doi.org/10.2147/BTT.S126725 Text en © 2018 Meng et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Meng, Hu
Deng, Shuai
You, Yajing
Chan, Hon Fai
The role of microfluidics in protein formulations with pre-programmed functional characteristics
title The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_full The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_fullStr The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_full_unstemmed The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_short The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_sort role of microfluidics in protein formulations with pre-programmed functional characteristics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284529/
https://www.ncbi.nlm.nih.gov/pubmed/30584273
http://dx.doi.org/10.2147/BTT.S126725
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