Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome

The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2...

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Detalles Bibliográficos
Autores principales: Lynch, Rebecca M, Mantus, Grace, Encinales, Liliana, Pacheco, Nelly, Li, Guangzhao, Porras, Alexandra, Mendoza, Alejandro R, Peng, Jin, Rengifo-Pardo, Monica, Cruz, Magelda Montoya, Harris, Eva, Bethony, Jeff M, Simon, Gary L, Chang, Aileen Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284544/
https://www.ncbi.nlm.nih.gov/pubmed/30113672
http://dx.doi.org/10.1093/infdis/jiy466
Descripción
Sumario:The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.

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