Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome

The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2...

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Autores principales: Lynch, Rebecca M, Mantus, Grace, Encinales, Liliana, Pacheco, Nelly, Li, Guangzhao, Porras, Alexandra, Mendoza, Alejandro R, Peng, Jin, Rengifo-Pardo, Monica, Cruz, Magelda Montoya, Harris, Eva, Bethony, Jeff M, Simon, Gary L, Chang, Aileen Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284544/
https://www.ncbi.nlm.nih.gov/pubmed/30113672
http://dx.doi.org/10.1093/infdis/jiy466
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author Lynch, Rebecca M
Mantus, Grace
Encinales, Liliana
Pacheco, Nelly
Li, Guangzhao
Porras, Alexandra
Mendoza, Alejandro R
Peng, Jin
Rengifo-Pardo, Monica
Cruz, Magelda Montoya
Harris, Eva
Bethony, Jeff M
Simon, Gary L
Chang, Aileen Y
author_facet Lynch, Rebecca M
Mantus, Grace
Encinales, Liliana
Pacheco, Nelly
Li, Guangzhao
Porras, Alexandra
Mendoza, Alejandro R
Peng, Jin
Rengifo-Pardo, Monica
Cruz, Magelda Montoya
Harris, Eva
Bethony, Jeff M
Simon, Gary L
Chang, Aileen Y
author_sort Lynch, Rebecca M
collection PubMed
description The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
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spelling pubmed-62845442018-12-11 Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome Lynch, Rebecca M Mantus, Grace Encinales, Liliana Pacheco, Nelly Li, Guangzhao Porras, Alexandra Mendoza, Alejandro R Peng, Jin Rengifo-Pardo, Monica Cruz, Magelda Montoya Harris, Eva Bethony, Jeff M Simon, Gary L Chang, Aileen Y J Infect Dis Major Articles and Brief Reports The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection. Oxford University Press 2019-01-01 2018-08-03 /pmc/articles/PMC6284544/ /pubmed/30113672 http://dx.doi.org/10.1093/infdis/jiy466 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Lynch, Rebecca M
Mantus, Grace
Encinales, Liliana
Pacheco, Nelly
Li, Guangzhao
Porras, Alexandra
Mendoza, Alejandro R
Peng, Jin
Rengifo-Pardo, Monica
Cruz, Magelda Montoya
Harris, Eva
Bethony, Jeff M
Simon, Gary L
Chang, Aileen Y
Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome
title Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome
title_full Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome
title_fullStr Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome
title_full_unstemmed Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome
title_short Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome
title_sort augmented zika and dengue neutralizing antibodies are associated with guillain-barré syndrome
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284544/
https://www.ncbi.nlm.nih.gov/pubmed/30113672
http://dx.doi.org/10.1093/infdis/jiy466
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