Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ(1) riboswitches in E.coli

For this study, we utilized class-I and class-II preQ(1)-sensing riboswitches as model systems to decipher the structure-activity relationship of rationally designed ligand derivatives in vitro and in vivo. We found that synthetic preQ(1) ligands with amino-modified side chains that protrude from th...

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Detalles Bibliográficos
Autores principales: Neuner, Eva, Frener, Marina, Lusser, Alexandra, Micura, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284575/
https://www.ncbi.nlm.nih.gov/pubmed/30332908
http://dx.doi.org/10.1080/15476286.2018.1534526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284575/
https://www.ncbi.nlm.nih.gov/pubmed/30332908
http://dx.doi.org/10.1080/15476286.2018.1534526

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