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Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ(1) riboswitches in E.coli
For this study, we utilized class-I and class-II preQ(1)-sensing riboswitches as model systems to decipher the structure-activity relationship of rationally designed ligand derivatives in vitro and in vivo. We found that synthetic preQ(1) ligands with amino-modified side chains that protrude from th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284575/ https://www.ncbi.nlm.nih.gov/pubmed/30332908 http://dx.doi.org/10.1080/15476286.2018.1534526 |