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Rapid, automated characterization of disulfide bond scrambling and IgG2 isoform determination
Human antibodies of the IgG2 subclass exhibit complex inter-chain disulfide bonding patterns that result in three structures, namely A, A/B, and B. In therapeutic applications, the distribution of disulfide isoforms is a critical product quality attribute because each configuration affects higher or...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284591/ https://www.ncbi.nlm.nih.gov/pubmed/30277844 http://dx.doi.org/10.1080/19420862.2018.1512328 |