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EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies
Bispecific antibody therapeutics can expand the functionality of a conventional monoclonal antibody drug because they can bind multiple antigens. However, their great potential is counterbalanced by the challenges faced in their production. The classic asymmetric bispecific containing an Fc requires...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284599/ https://www.ncbi.nlm.nih.gov/pubmed/30215570 http://dx.doi.org/10.1080/19420862.2018.1519631 |