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Synthetic lethal combinations of low-toxicity drugs for breast cancer identified in silico by genetic screens in yeast
In recent years, the concept of synthetic lethality, describing a cellular state where loss of two genes leads to a non-viable phenotype while loss of one gene can be compensated, has emerged as a novel strategy for cancer therapy. Various compounds targeting synthetic lethal pathways are either und...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284748/ https://www.ncbi.nlm.nih.gov/pubmed/30555636 http://dx.doi.org/10.18632/oncotarget.26372 |